Systemic factors responsible for cross-transfer effect of muscle hypertrophy after resistance exercise training

抗阻运动训练后肌肉肥大交叉转移效应的全身因素

• 批准号: 21300235
• 负责人: ISHII Naokata
• 金额: $ 11.23万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21300235/
• 关键词: レジスタンストレーニング; 筋肥大; 効果転移; 循環因子; プロテオーム解析; 培養筋芽細胞; シグナル伝達系; 運動・トレーニング; プオテオーム解析; 培養筋細胞; タンパク質合成; ショットガン解析; 血流制限

A low-intensity resistance training for upper arm muscles, if ineffective for muscle hypertrophy, can cause muscle hypertrophy when combined with a resistance training with vascular occlusion for thigh muscles("cross-transfer" of muscle hypertrophy ; Madarame et al., 2008). The present study investigated the role played by systemic factors in this cross-transfer effect. Training experiments with humans showed that conventional, high-intensity resistance training can also cause the similar cross-transfer effect. In addition, proteomic analysis of serum samples taken before and after the training with vascular occlusion showed significant changes in the concentration of several growth factors. When serum was taken from rats subjected to high-intensity resistance training and then added to cultured myoblasts, it caused significant changes in signal transduction substrates related to protein synthesis. These results suggest that some growth factors within serum play important parts in the cross-transfer effect of muscle hypertrophy.

如果对肌肉肥大无效，对上臂肌肉进行低强度的耐药性训练，当与大腿肌肉的血管闭塞抗性训练结合使用时，可能会导致肌肉肥大（Madarame等，2008） 。本研究调查了系统因素在这种跨转移效应中所起的作用。对人类进行的训练实验表明，常规的高强度耐药性训练也会引起相似的跨转移效应。此外，对血管闭塞训练之前和之后进行的血清样品的蛋白质组学分析显示，几种生长因子的浓度有显着变化。当从接受高强度耐药性训练的大鼠中抽取血清，然后添加到培养的肌细胞中时，它会导致与蛋白质合成相关的信号转导底物的显着变化。这些结果表明，血清内的某些生长因子在肌肉肥大的跨转移作用中起重要的作用。

项目成果

Significant roles of microtubules in mature striated muscle deduced from the correlation between tubulin and its molecular chaperone alpha B-crystallin in rat muscles

从大鼠肌肉中微管蛋白与其分子伴侣αB-晶状体蛋白之间的相关性推论微管在成熟横纹肌中的重要作用

• 发表时间: 2009
• 期刊: J. Physiol. Sci.
• 作者: Jee;H.;Sakurai;T.;Kawada;S.;Ishii;N. and Atomi;Y
• 通讯作者: Y

Roles played by protein metabolism and myogenic progenitor cells in exercise-induced muscle hypertrophy and their relation to resistance training regimens

蛋白质代谢和肌源性祖细胞在运动引起的肌肉肥大中发挥的作用及其与阻力训练方案的关系

• 发表时间: 2012
• 期刊: J. Phys. Fitness Sports Med.
• 作者: Ishii;N.;Ogasawara;R.;Kobayashi;K. and Nakazato;K
• 通讯作者: K

Increased oxygen tension attenuates acute ultraviolet-B-induced skin angiogenesis and wrinkle formation

• DOI: 10.1152/ajpregu.00199.2010
• 发表时间: 2010-08-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
• 影响因子: 2.8
• 作者: Kawada, Shigeo;Ohtani, Masaru;Ishii, Naokata
• 通讯作者: Ishii, Naokata

Suppression of UVB-induced HIF-1αup-regulation by hyperoxia does not prevent wrinkle formation associated with increased MMPs activity in mouse skin

通过高氧抑制 UVB 诱导的 HIF-1α 上调并不能阻止小鼠皮肤中与 MMP 活性增加相关的皱纹形成

• 发表时间: 2011
• 期刊: Biomed. Res.
• 作者: Kawada;S. and Ishii;N
• 通讯作者: N

Time course change of IGF-1/Akt/mTOR/p7OS6K pathway activation in rat gastrocnemius muscle during repeated bouts of eccentric exercise.

重复进行离心运动期间大鼠腓肠肌 IGF-1/Akt/mTOR/p7OS6K 通路激活的时程变化。

• 发表时间: 2010
• 期刊: J.Sports Sci.Med. (In press)
• 作者: Ochi;E.;Ishii;N.;Nakazato;K.
• 通讯作者: K.