The development of image-guided and electrophysiological navigation for deep brain stimulation surgery

深部脑刺激手术的图像引导和电生理导航的发展

• 批准号: 21300188
• 负责人: YASUKAZU Kajita
• 金额: $ 11.56万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21300188/
• 关键词: 脳深部刺激術; パーキンソン病; ナビゲーション; 3D手術支援画像; 定位的脳深部刺激術; 単一神経活動; 3D画像; 視床下核; 大脳基底核; 淡蒼球; 画像解析

Deep brain stimulation(DBS) of the subthalamic nucleus(STN) for the patients with Parkinson disease(PD) is performed using intraoperative microelectrode recording(MER) to define the optimal site. The correlation between microelectrode criteria and surgical outcome was respectively examined in the patients with STN DBS. The number of total STN neurons, movement-related neurons and the length of STN recorded were significantly correlated with improvement of the surgical outcome and the number of movement-related neurons was most strongly related with the surgical outcome. We developed the new image analysis technique based on non-linear transformation theory. The brain shift is evaluated according to the volume of free air in the skull X-P(front and lateral view) taken intraoperatively, resulting calculation of AC and PC displacement. Totally, we developed the electrophysiological navigation of which the single unit recording data significantly correlated to the surgical outcome is considered and the real-time electrophysiological data can be fitted to the 3Dvirtual Schaltenbland and Wahren atlas

使用术中微电极记录（MER）对帕金森氏病（PD）患者的丘脑下核（STN）的深脑刺激（DB）进行定义。在STN DBS患者中，分别检查了微电极标准与手术结果之间的相关性。与手术结局的改善显着相关，与运动相关的总体神经元，运动相关的神经元的总数和运动相关神经元的数量显着相关，与手术结果最密切相关。我们基于非线性转换理论开发了新的图像分析技术。根据术中对颅骨X-P（前视图和侧视图）中的自由空气的体积评估脑移位，从而导致AC和PC位移的计算。总的来说，我们开发了电生理导航，该导航的单个单元记录数据与手术结果显着相关，并且可以将实时电生理数据拟合到3DVIRTUAL SCHALTENBLAND和WAHREN ATLAS

项目成果

パーキンソン病に対する視床下核刺激術における単一神経活動と長期効果

丘脑底核刺激治疗帕金森病的单一神经活动和长期效果

• 发表时间: 2011
• 期刊: 機能的脳神経外科
• 作者: Nishida K;Doita M;Kakutani K;Maeno K;Yurube T;Kurosaka M;梶田泰一
• 通讯作者: 梶田泰一

Computational anatomy for CAD-CAS integration

CAD-CAS 集成的计算解剖学

• 发表时间: 2010
• 作者: 佐野肇;櫻井大輔;和田健司;松中敏行;堀中博道;Kensaku Mori
• 通讯作者: Kensaku Mori

Development of a real-time tactile sensing system for brain tumor diagnosis

开发用于脑肿瘤诊断的实时触觉传感系统

• 发表时间: 2010
• 期刊: Int. J. of Computer Assisted Radiology and Surgery
• 作者: Yoshihiro Tanaka;Qingyun Yu;Kazuki Doumoto;Akihito Sano;Yuichiro Hayashi;Masazumi Fujii;Yasukazu Kajita;Masaaki Mizuno;Toshihiko Wakabayashi and Hideo Fujimoto
• 通讯作者: Toshihiko Wakabayashi and Hideo Fujimoto

Synchronized Display of Virtual Colonoscopic Views in Supine and Prone CT Images

同步显示仰卧位和俯卧位 CT 图像中的虚拟结肠镜视图

• 发表时间: 2010
• 期刊: Proceedings of MICCAI 2010 Workshop : Virtual Colonoscopy & Abdominal Imaging
• 作者: Masahiro Oda;Eiichiro Fukano;Takayuki Kitasaka;Hirotsugu Takabatake;Masaki Mori;Hiroshi Natori;Shigeru Nawano;and Kensaku Mori
• 通讯作者: and Kensaku Mori

ボリュームレンダリング画像におけるテキスト情報の表示方法とその手術支援画像

如何在体绘制图像及其手术支持图像中显示文本信息

• 发表时间: 2010
• 作者: 蒋振剛