Physiological Function of Hormones Derived from Mesenchymal Cells and Its Failure

间充质细胞激素的生理功能及其失效

• 批准号: 21229013
• 负责人: NAKAO Kazuwa
• 金额: $ 135.62万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (S)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009-05-11 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21229013/
• 关键词: 内分泌学; 間葉系細胞由来ホルモン; ホルモン; 間葉系; 内分泌; レプチン; CNP; ナトリウム利尿ペプチド; レプシン; 軟骨; 脂肪組織; 脂肪委縮症; 間葉系細胞; 脂肪細胞; 心血管構成細胞; 肥満; 脂肪萎縮症; ANP; GC-B; レブチン

We demonstrated that the BP of CNP ecKO mice is significantly elevated. Their vascular relaxation reaction of mesenteric artery was diminished significantly. We showed that circulating CNP rescues chondrodysplastic CNP ko mice from impaired skeletal growth. We revealed that GC-A protects podocytes from aldosterone-induced glomerular injury.We demonstrated the insufficiency of postprandial suppression of food-related neural activity by fMRI and satiety feeling in lipodystrophic patients, which was restored by leptin, and that the beneficial effect of leptin /amylin coadministration on glucose and lipid metabolism in DIO mice. Owing to our investigator-initiated trial, marketing and manufacturing of recombinant human leptin for lipodystrophy were approved in 2013 in Japan. We demonstrated on adipogenic potential of human iPS/ES cells in vitro, and that these adipocytes can survive for at least 4 weeks after transplantation.

我们证明了CNP Ecko小鼠的BP显着升高。它们的肠系膜动脉血管松弛反应显着减少。我们表明，循环CNP使软骨发育异常CNP KO小鼠免于骨骼生长受损。我们揭示了GC-A可保护足细胞免受醛固酮诱导的肾小球损伤。我们证明了餐后抑制餐后通过fMRI抑制食物相关的神经活动的不足，而脂肪营养不良患者中的饱腹感是由瘦素恢复的，并且是瘦素的效应。 /在DIO小鼠中葡萄糖和脂质代谢的淀粉蛋白共同给药。由于我们的研究人员发起的试验，2013年在日本批准了重组人类瘦素的脂肪营养不良蛋白的营销和制造。我们证明了人IPS/ES细胞在体外的脂肪生成潜力，并且这些脂肪细胞可以在移植后至少生存4周。

项目成果

Skeletal Analysis of the Long Bone Abnormality (lbab/lbab) Mouse, A Novel Chondrodysplastic C-Type Natriuretic Peptide Mutant

• DOI: 10.1007/s00223-011-9567-0
• 发表时间: 2012-04-01
• 期刊: CALCIFIED TISSUE INTERNATIONAL
• 影响因子: 4.2
• 作者: Kondo, Eri;Yasoda, Akihiro;Nakao, Kazuwa
• 通讯作者: Nakao, Kazuwa

Translational research of C-type natriuretic peptide (CNP) into skeletal dysplasias.

• DOI: 10.1507/endocrj.k10e-164
• 发表时间: 2010-08
• 期刊: Endocrine journal
• 影响因子: 2
• 作者: A. Yasoda;K. Nakao

Transcriptional Regulation of the Fetal Cardiac Gene Program

• DOI: 10.1254/jphs.12r04cp
• 发表时间: 2012-07-01
• 期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES
• 影响因子: 3.5
• 作者: Kuwahara, Koichiro;Nishikimi, Toshio;Nakao, Kazuwa
• 通讯作者: Nakao, Kazuwa

Glucocorticoid reamplification within cells intensifies NF-kappaB and MAPK signaling and reinforces inflammation in activated preadipocytes.

细胞内的糖皮质激素再放大会增强 NF-κB 和 MAPK 信号传导，并增强激活的前脂肪细胞中的炎症。

• 发表时间: 2010
• 期刊: Am J Physiol Endocrinol Metab.
• 作者: Ishii-Yonemoto T;Nakao K.;et al
• 通讯作者: et al

レプチンのトランスレーショナルサイエンス

瘦素的转化科学

• 发表时间: 2012
• 作者: 中尾一和;他
• 通讯作者: 他