Mechanism for genomic instability during inflammation-associated carcinogenesis

炎症相关致癌过程中基因组不稳定性的机制

• 批准号: 21229009
• 负责人: CHIBA Tsutomu
• 金额: $ 100.01万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (S)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21229009/
• 关键词: 上部消化管学; 消化器発癌; AID; 遺伝子変異; メチル化; 遺伝子不安定性; H.pylori; 癌幹細胞; Colitic cancer; APOBEC2; 上部消化管学; 消化器発癌; AID; 遺伝子変異; メチル化; 遺伝子不安定性; H.pylori; 癌幹細胞; Colitic cancer; APOBEC2

Many cancers arise with the background of inflammation, and cancerdevelopment is associated with accumulation of various gene aberrations.Activation-induced cytidine deaminase (AID) is exclusively expressed in B lymphocytesand plays important roles in induction of class-switch recombination (CSR) and somatichypermutation (SHM) of the immunoglobulin (Ig) genes, resulting in diversification ofIg genes in physiological condition. We found in this study that AID is ectopicallyexpressed in epithelial cells during inflammation, and is involved ininflammation-associated cancer development by inducing various gene aberrationsincluding gene mutations and deletions and duplications in epithelial cells.

Many cancers arise with the background of inflammation, and cancerdevelopment is associated with accumulation of various gene aberrations.Activation-induced cytidine deaminase (AID) is exclusively expressed in B lymphocytesand plays important roles in induction of class-switch recombination (CSR) and somatichypermutation (SHM) of the immunoglobulin (Ig) genes, resulting in在生理状况下的杂志基因的多样化。我们在这项研究中发现，在炎症过程中，AID在上皮细胞中被异位表达，并且通过诱导各种基因畸变（包括基因突变以及上皮细胞中的缺失和重复），涉及与炎症相关的癌症发育。