The various clinical applicability of cultured oral epithelial cells sheet on amniotic membrane

羊膜培养口腔上皮细胞片的多种临床适用性

• 批准号: 21592535
• 负责人: KANAMURA Narisato
• 金额: $ 2.66万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592535/
• 关键词: 口腔外科一般(含病態検査学); 移植・再生医療; 再生医学; 細胞・組織; 歯学; 臨床

Autologous oral mucosal epithelial sheets, which were cultivated on amniotic membrane, were used for the transplantation of oral mucosa after oral surgery(9 cases : mucocele ; oral leukoplakia ; pleomorphic adenoma ; lip neoplasm ; and fibroma of buccal mucosa). In 7 of these cases, a favorable post-transplant course was obtained with reproduced oral mucosa without abnormalities at the transplantation site. On the other hand, transplant approaches were not applicable in the remaining 2 cases, in which the diseased portion was removed, involving a substantial loss, suggesting the necessity of examining the appropriate selection of patients and surgical procedures for transplantation.

采用在羊膜上培养的自体口腔粘膜上皮片，用于口腔手术后口腔粘膜移植（粘液囊肿、口腔白斑、多形性腺瘤、唇肿瘤、颊粘膜纤维瘤9例）。其中 7 例获得了良好的移植后病程，口腔粘膜再生，移植部位没有异常。另一方面，其余2例不适用移植方法，病灶部分被切除，损失较大，提示有必要研究合适的移植患者选择和手术方式。

项目成果

Immunohistochemical study of oral epithelial sheets cultured on amniotic membrane for oral mucosal reconstruction

• DOI: 10.3233/bme-2010-0613
• 发表时间: 2010-01-01
• 期刊: BIO-MEDICAL MATERIALS AND ENGINEERING
• 影响因子: 1
• 作者: Amemiya, Takeshi;Nakamura, Takahiro;Kanamura, Narisato
• 通讯作者: Kanamura, Narisato

ヒト羊膜を用いた新たな歯周組織再生法の開発

利用人羊膜开发牙周组织再生新方法

• 发表时间: 2013
• 期刊: 日本歯科医学会誌
• 作者: 雨宮傑;中村隆宏;本城賢一;熊本園子;足立圭司;山本俊郎;木下茂;金村成智
• 通讯作者: 金村成智

口腔組織を用いた再生医療アンチエイジングをめざした新たな歯周組織再生法の開発

利用口腔组织开发抗衰老再生医学牙周组织再生新方法

• 发表时间: 2012
• 作者: Norifumi Kiga;Itaru Tojyo;Takashi Matsumoto;Yukihiro Hiraishi;Yuji Shinohara;Shigeyuki Fujita;金村成智
• 通讯作者: 金村成智

Tissue engineering by transplantation of oral epithelial sheets cultivated on amniotic membrane for oral mucosal reconstruction

• DOI: 10.2492/inflammregen.30.176
• 发表时间: 2010-01-01
• 期刊: Inflamm Regen
• 影响因子: 8.1
• 作者: Amemyia, T.;Nakamura, T.;Kanamura, N.
• 通讯作者: Kanamura, N.

Tissue engineering with using of cultured oral epithelial sheets on amniotic membrane

利用羊膜上培养的口腔上皮片进行组织工程

• 发表时间: 2009
• 作者: Takeshi Amemiya;Takahiro Nakamura;Keiji Adachi;Toshiro Yamamoto;Shigeru Kinoshita;Narisato Kanamura
• 通讯作者: Narisato Kanamura