Ananlysis of the retinal degenerative diseases using iPS cells

使用 iPS 细胞分析视网膜退行性疾病

• 批准号: 21592265
• 负责人: OZAWA Yoko
• 金额: $ 2.91万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592265/
• 关键词: 網膜; 視細胞; 再生; iPS; 神経保護

We analyzed the pathogenesis of the retinal degenerative diseases using iPS cell-induced retinal cells. We generated the iPS cell which conserves patient's gene sequences. Retinal cells were induced both from control iPS cells and the patient-derived iPS cells, and analyzed the characteristics of the cells. This research was valuable to clarify the pathogenesis of the retinal degenerative disease, and further study is now required to explore a new therapeutic approach.

我们使用IPS细胞诱导的视网膜细胞分析了视网膜退行性疾病的发病机理。我们生成了保存患者基因序列的IPS细胞。从对照IPS细胞和患者来源的IPS细胞中诱导了视网膜细胞，并分析了细胞的特征。这项研究对于阐明视网膜退行性疾病的发病机理非常有价值，现在需要进一步的研究来探索一种新的治疗方法。

项目成果

Resveratrol Prevents Light-Induced Retinal Degeneration via Suppressing Activator Protein-1 Activation

• DOI: 10.2353/ajpath.2010.100098
• 发表时间: 2010-10-01
• 期刊: AMERICAN JOURNAL OF PATHOLOGY
• 影响因子: 6
• 作者: Kubota, Shunsuke;Kurihara, Toshihide;Tsubota, Kazuo
• 通讯作者: Tsubota, Kazuo

Inflammatory Signals in the Pathogenesis of Diabetic Retinopathy

糖尿病视网膜病变发病机制中的炎症信号

• 发表时间: 2011
• 作者: Iwata D;Namba K;Mizuuchi K;Kitaichi N;Kase S;Takemoto Y;Ohno S;Ishida S.;Yoko Ozawa
• 通讯作者: Yoko Ozawa

Neuroprotective effect of an antioxidant lutein in light-induced retinal degeneration.

抗氧化剂叶黄素在光诱导的视网膜变性中的神经保护作用。

• 发表时间: 2010
• 作者: Sasaki M;Ozawa Y;Kurihara T;Kubota S;Yuki K;Noda K;Kobayashi S;Ishida S;Tsubota K.
• 通讯作者: Tsubota K.

Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes.

• DOI: 10.1007/s00125-009-1655-6
• 发表时间: 2010-05
• 期刊: DIABETOLOGIA
• 影响因子: 8.2
• 作者: Sasaki, M.;Ozawa, Y.;Kurihara, T.;Kubota, S.;Yuki, K.;Noda, K.;Kobayashi, S.;Ishida, S.;Tsubota, K.
• 通讯作者: Tsubota, K.

Transcriptional factors associated with epithelial-mesenchymal transition in choroidal neovascularization

• 发表时间: 2009-04
• 期刊: Molecular Vision
• 影响因子: 2.2
• 作者: Manabu Hirasawa;K. Noda;S. Noda;Misa Suzuki;Y. Ozawa;K. Shinoda;M. Inoue;Y. Ogawa;K. Tsubota;S. Ishida