Investigation into the cerebral mechanisms of chronic pain using functional magnetic resonance imaging

使用功能磁共振成像研究慢性疼痛的脑机制

• 批准号: 21592004
• 负责人: KURATA Jiro
• 金额: $ 2.83万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592004/
• 关键词: 疼痛管理学; 疼痛診断; 機能的磁気共鳴画像法; 慢性疼痛; 腰痛; 神経障害性疼痛; アロディニア; 後帯状皮質; 大脳辺縁系; Default mode network; 大脳辺緑系; 深部痛; 麻酔深度

We used lumbar mechanical stimulation and functional magnetic resonance imaging(fMRI) and found that cerebral substrates of low back pain are distributed at the insular, posterior cingulate, prefrontal cortices and premotor area. Low back pain patients showed significantly enhanced activation at the posterior cingulate cortex(PCC) compared with healthy volunteer subjects. The size of activation at the PCC depended on the intensity of lumbar mechanical stimulation. The enhanced PCC activation was associated with dysfunction of the surrounding default mode network in chronic low back pain patients, which might explain the pathophysiological background of cognitive dysfunction in those patients. In a different series of studies, fMRI successfully unveiled exaggerated activation over wide brain areas including the limbic system in neuropathic pain and, in contrast, normal somatosensory activation in psychogenic pain.In summary, chronic pain patients showed exaggerated activation at the cerebral substrates of pain perception in the limbic system, especially at the posterior cingulate cortex, and a sign of potentially disturbed function of the default mode network. Analysis of pain-related cerebral activation by fMRI might potentially give an objective clue to differentiate neuropathic and psychogenic pain.

我们使用了腰部机械刺激和功能性磁共振成像（fMRI），发现下背部疼痛的脑底物分布在岛状的，后扣带回，前额叶皮层和前体区域。与健康的志愿者相比，在后扣带回皮层（PCC）处，腰痛患者的激活显着增强。 PCC激活的大小取决于腰部机械刺激的强度。增强的PCC激活与慢性腰痛患者中周围默认模式网络的功能障碍有关，这可能解释了这些患者认知功能障碍的病理生理背景。 In a different series of studies, fMRI successfully unveiled exaggerated activation over wide brain areas including the limbic system in neuropathic pain and, in contrast, normal somatosensory activation in psychogenic pain.In summary, chronic pain patients showed exaggerated activation at the cerebral substrates of pain perception in the limbic system, especially at the posterior cingulate cortex, and a sign of potentially disturbed function of the默认模式网络。 fMRI对与疼痛相关的脑激活的分析可能有可能为区分神经性和心理疼痛的客观线索提供了分析。

项目成果

The effects of vibratory therapy on chronic painafter median nerve injury-abehavioral and fMRI study

振动疗法对正中神经损伤后慢性疼痛的影响——行为和功能磁共振成像研究

• 发表时间: 2010
• 作者: Kurata J;他2名
• 通讯作者: 他2名

慢性疼痛における治療効果判定

判断慢性疼痛的治疗效果

• 发表时间: 2011
• 作者: Yoshitaka Kobayashi;Jiro Kurata;et al.;倉田二郎;倉田二郎
• 通讯作者: 倉田二郎

Corticocortical evoked potential monitoring as a tool to investigate anesthetic-induced unconsciousness : a preliminary report

皮质诱发电位监测作为研究麻醉引起的无意识的工具：初步报告

• 发表时间: 2011
• 作者: Yoshitaka Kobayashi;Jiro Kurata;et al.;倉田二郎;倉田二郎;倉田二郎;倉田二郎;Kurata J;Kurata J;Kurata J;倉田二郎;Kurata J
• 通讯作者: Kurata J

意識の可視化は可能か-機能的脳画像法が解明する意識と麻酔のメカニズム-

意识可视化是否可能？ - 通过功能性脑成像阐明意识和麻醉机制 -

• 发表时间: 2012
• 期刊: LiSA
• 作者: Kopman AF;Kurata J;倉田二郎;倉田二郎
• 通讯作者: 倉田二郎

機能的脳画像法から見た全身麻酔薬作用機序

从功能性脑成像观察全身麻醉药的作用机制

• 发表时间: 2011
• 期刊: 麻酔
• 作者: Kopman AF;Kurata J;倉田二郎
• 通讯作者: 倉田二郎