Endovascular treatment of experimental aneurysms in swine model by use of mesenchymal stem cells-coated stents.

使用间充质干细胞涂层支架对猪模型中的实验性动脉瘤进行血管内治疗。

• 批准号: 21591852
• 负责人: IIHOSHI Satoshi
• 金额: $ 2.91万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591852/
• 关键词: 移植再生医療; 脳血管内治療; 再生医学; 神経科学; 発生分化

The purpose of this study was to determine whether implanting exogenous mesenchymal stem cells on stents could enhance aneurysmal neck healing. I thought hypotheses included that mesenchymal stem cells-coated stents can improve angiographic and histopathologic results after endovascular treatment. Mesenchymal stem cells-coated stents were not effective for accelerating organization of the aneurysms cavity and developing neointima after endovascular treatment. This is a promising novel procedure to repair aneurysm , and may provide a new way to induce plasticity in mesenchymal stem cells.

这项研究的目的是确定在支架上植入外源间充质干细胞是否可以增强动脉瘤颈部愈合。我认为包括假设是间充质干细胞包被的支架可以改善血管内治疗后的血管造影和组织病理学结果。间充质干细胞涂层的支架对于加速动脉瘤腔的组织并在血管内治疗后发育新内膜无效。这是修复动脉瘤的有前途的新型程序，可以提供一种诱导间充质干细胞可塑性的新方法。