Association of linkage between autoantigens and, ubiquitin. proteasome system in autoantibody production

自身抗原和泛素之间的联系。

• 批准号: 21591271
• 负责人: TAKASAKI Yoshinari
• 金额: $ 2.83万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591271/
• 关键词: autoantigen; proteasome; ubiquitin; autoantibody; autoanitibody; ubiqutin; 自己免疫

We studied immune response to components of proteasome using sera from patients with various connective tissue diseases by immunoblotting. Then, we found that there is a linkage of autoimmune response among components of proteasome and their binding proteins. In addition, We found that circulating proteasome detected by sandwich type ELISA is significantly associated with autoimmune response to proteasome and its binding proteins. These results suggested that the circulating ubiquitin-proteasome complex binding with autoantigens in association with its biologic function is playing an important role to induce autoimmune response to its binding antigens.

我们通过免疫印迹研究了使用患有各种结缔组织疾病的患者的血清对蛋白酶体成分的免疫反应。然后，我们发现蛋白酶体成分与其结合蛋白之间存在自身免疫反应的联系。此外，我们发现夹心型 ELISA 检测到的循环蛋白酶体与蛋白酶体及其结合蛋白的自身免疫反应显着相关。这些结果表明，与自身抗原结合的循环泛素-蛋白酶体复合物与其生物学功能相关，在诱导对其结合抗原的自身免疫反应中发挥着重要作用。

项目成果

全身性エリテマトーデス,リウマチ・膠原病内科クリニカルスタンダード

系统性红斑狼疮、风湿/胶原病内科临床标准

• 发表时间: 2010
• 作者: Owada T;Watanabe N;Oki M;Oya Y;Murphy KM;Nakajima H;他4名;高崎芳成
• 通讯作者: 高崎芳成

Anti-Ro/SSA Antibodies Are an Independent Factor Associated with an Insufficient Response to Tumor Necrosis Factor Inhibitors in Patients with Rheumatoid Arthritis

• DOI: 10.3899/jrheum.101295
• 发表时间: 2011-11-01
• 期刊: JOURNAL OF RHEUMATOLOGY
• 影响因子: 3.9
• 作者: Matsudaira, Ran;Tamura, Naoto;Takasaki, Yoshinari
• 通讯作者: Takasaki, Yoshinari

Single-center, retrospective analysis of efficacy and safety of tacrolimus as a second-line DMARD in combination therapy and the risk factors contributing to adverse events in 115 patients with rheumatoid arthritis

• DOI: 10.1007/s10067-011-1810-6
• 发表时间: 2012-02-01
• 期刊: CLINICAL RHEUMATOLOGY
• 影响因子: 3.4
• 作者: Ogasawara, Michihiro;Tamura, Naoto;Takasaki, Yoshinari
• 通讯作者: Takasaki, Yoshinari

Autoantibodies in Connective Tissue Diseases-Its Mechanism of Production and Clinical Significance

结缔组织病自身抗体的产生机制及临床意义

• 发表时间: 2009
• 作者: Kanari H;Kagami S;Kashiwakuma D;Oya;Hirose K;Watanabe N;Nakajima H;他7名;作田建夫;Takasaki Y
• 通讯作者: Takasaki Y

膠原病

胶原病

• 发表时间: 2009
• 作者: Kashiwakuma D;Suto A;Hirose;K Watanabe N;Nakajima H.;他6名;高崎芳成
• 通讯作者: 高崎芳成