Mechanisms of the increased maternal transmission of neonatal asthma risks by exposure to air-pollution.

接触空气污染导致新生儿哮喘风险增加的母亲传播机制。

• 批准号: 21590969
• 负责人: HAMADA Kaoru
• 金额: $ 2.5万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590969/
• 关键词: 気管支喘息; 大気汚染; 喫煙Th2サイトカイン; エピジェネティクス; 喫煙; 室内気(indoor-air); 室内大気(in-door air); ホルムアルデヒド

Increased incidence of asthma and other allergic diseases are the worldwide problem. Air-pollution is recognized as one of the important factor for pathogenesis of asthma. We have investigated whether exposure to air-pollution such as oil fly as, formaldehyde and tobacco smoking during pregnancy can contribute to development of asthma in the offspring. Data indicated neonatal mice from mothers exposed to pollutants before delivery could express asthma manifestation by the suboptimal sensitization. As the mechanism(s), these mice showed the persistent Th2-dominant immune profile after birth. Contribution of epigenetics to this maternal transmission or transplacental effect of asthma susceptibility should be clarified.

哮喘和其他过敏性疾病的发生率增加是全球问题。空气污染被认为是哮喘发病机理的重要因素之一。我们已经调查了在怀孕期间吸烟，甲醛和烟草吸烟等空气污染的暴露是否会导致后代哮喘的发展。数据表明，在分娩前暴露于污染物的母亲的新生小鼠可以通过次优敏化表达哮喘表现。作为机制，这些小鼠在出生后显示出持续的Th2主导免疫特征。应阐明表观遗传学对哮喘易感性的这种母体传播或移植作用的贡献。

项目成果

Clinical Significance of Prostate Stem Cell Antigen Expression in Non-small Cell Lung Cancer

• DOI: 10.1093/jjco/hyp181
• 发表时间: 2010-04-01
• 期刊: JAPANESE JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 2.4
• 作者: Kawaguchi, Takeshi;Sho, Masayuki;Taniguchi, Shigeki
• 通讯作者: Taniguchi, Shigeki

Exposure of Pregnant Mice to Cigarette Smoke Extract Increases Asthma Susceptibility in Offspring

怀孕小鼠接触香烟烟雾提取物会增加后代哮喘的易感性

• 发表时间: 2010
• 作者: Hamada K;Suzaki Y;Kimura H
• 通讯作者: Kimura H

胎児期の室内空気汚染曝露が喘息発症に及ぼす影響についての検討

胎儿接触室内空气污染对哮喘发病影响的研究

• 发表时间: 2009
• 作者: 濱田薫、須崎康恵、木村弘;筏義人
• 通讯作者: 筏義人

Exposure of pregnant mice to cigarette smioke extract increases asthma susceptibility in offspring

怀孕小鼠接触香烟烟雾提取物会增加后代的哮喘易感性

• 发表时间: 2010
• 作者: Hamada K;Suzaki Y;Kimura H
• 通讯作者: Kimura H

An autopsy case of porto-pulmonary hypertension associated with alcoholic liver cirrhosis

酒精性肝硬化门脉性肺动脉高压尸检一例

• 发表时间: 2011
• 期刊: Journal of Nara Medical Association
• 作者: Maruyama H;Toyoda-Hirana Y;Nakamura T;Enomoto Y;Hamada K;Kimura H
• 通讯作者: Kimura H