Role of expression of HAI-1 and LRP11 in Lung Cnacer

HAI-1和LRP11在肺癌中表达的作用

• 批准号: 21590375
• 负责人: TANAKA Hiroyuki
• 金额: $ 2.91万
• 依托单位: University of Miyazaki
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590375/
• 关键词: 肺癌; HGF : Hepatocyte growth factor; HGF activator inhibitor type-1; LRP11 : Low density lipoprotein receptor-related protein 11; HGF:Hepatocyte growth factor; HAI-1:HGF activator inhibitor type-1; LRP11:Low density lipoprotein receptor-related prote

1. We found that HAI-1 is expressed by the bronchial respiratory epithelium with basolateral localization.2. In the injured pulmonary tissue, HAI-1 showed distinct apical translocation in ciliated epithelial cells of the bronchiole.3. Distinct expression of LRP mRNA was observed in the brain, prostate, testis and lung tissue.4. Expression of LRP11 mRNA was increased in non-small cell lung cancer as compared with normal lung tissue.5. In pulmonary adenocarcinoma group, the correlation of clinicopathologic stage and expression ofLRP11 mRNA was suggested.6. In pulmonary squamous cell carcinoma group, expression of LRP11 mRNA appears to be increased as compared with normal lung tissue.

1.我们发现HAI-1由支气管呼吸道上皮表达，定位于基底外侧。2．在损伤的肺组织中，HAI-1在细支气管纤毛上皮细胞中表现出明显的顶端转位。3． LRP mRNA在脑、前列腺、睾丸和肺组织中均有明显表达。 4．非小细胞肺癌组织中LRP11 mRNA表达较正常肺组织升高。5．探讨肺腺癌临床病理分期与LRP11 mRNA表达的相关性。 6．在肺鳞状细胞癌组中，与正常肺组织相比，LRP11 mRNA的表达似乎增加。

项目成果

Tissue injury alters the site of expression of hepatocyte growth factor activator inhibitor type 1 in bronchial epithelial cells

• DOI: 10.1111/j.1749-0774.2008.00062.x
• 发表时间: 2009-02
• 期刊: Human Cell
• 影响因子: 4.3
• 作者: Hiroyuki Tanaka;T. Fukushima;K. Yorita;M. Kawaguchi;H. Kataoka

Improvement of Rheumatoid Arthritis and Autoimmune Hepatitis in a Patient Treated with the Tumor Necrosis Factor Inhibitor, Etanercept

使用肿瘤坏死因子抑制剂依那西普治疗的患者的类风湿关节炎和自身免疫性肝炎得到改善

• DOI: 10.2169/internalmedicine.50.4879
• 发表时间: 2011
• 期刊: Internal Medicine
• 影响因子: 1.2
• 作者: Umekita K;Miyauchi S;Ueno S;Takajo I;Kusumoto K;Hasuike S;Umekita Y;Tanaka H;Nagata K;Nagatomo Y;Kataoka H;Shimoda K;Okayama A
• 通讯作者: Okayama A

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• 发表时间: 2009
• 作者: 佐藤信也;徳満貴子;佐藤勇一郎;神田修司;大野昭信;丸塚浩助;田中弘之
• 通讯作者: 田中弘之

多彩な組織像を示した卵巣明細胞腺癌の一剖検例

卵巢透明细胞腺癌尸检一例显示不同组织学

• 发表时间: 2010
• 作者: Sato Y;Moriguchi-Goto S;Hatakeyama K;Marutsuka K;Asada Y;田中弘之
• 通讯作者: 田中弘之

Dickkopf-1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth

• DOI: 10.1002/ijc.24865
• 发表时间: 2010-04-01
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Takahashi, Nobuyasu;Fukushima, Tsuyoshi;Kataoka, Hiroaki
• 通讯作者: Kataoka, Hiroaki