Combined application of TMS/tDCS with intensive occupational therapy for upper limb hemiparesis

TMS/tDCS联合强化作业治疗治疗上肢偏瘫

• 批准号: 21500493
• 负责人: KAKUDA Wataru
• 金额: $ 2.41万
• 依托单位: Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21500493/
• 关键词: 経頭蓋磁気刺激; 経頭蓋直流電気刺激; 脳卒中; 機能回復; 上肢麻痺; 作業療法; 痙縮; TMS; tDCS

The main purpose of this study was to clarify the most beneficial therapeutic approach for upper limb hemiparesis after stroke among some modalities of repetitive transcranial magnetic stimulation(RTMS) and transcranial direct current stimulation(TDCS), and to investigate the clinical effect of combined application of RTMS/TDCS and intensive rehabilitative training. As a result, consecutive application of low-frequency RTMS over the non-lesional hemisphere with intensive occupational therapy was safe and seemed to have a potential to improve motor function of the affected upper limb in post-stroke patients. In addition, this combination significantly reduced abnormally increased muscle tonus of the affected upper limb, indicating the anti-spastic effect of the intervention. Unfortunately, the effect of TDCS on upper limb motor function after stroke has not been elucidated sufficiently so far, because of unexpected mechanical trouble with the device.

这项研究的主要目的是阐明在某些重复的经颅磁刺激（RTMS）和经颅直接电流刺激（TDC）的某些方式中，上肢偏瘫的最有益的治疗方法，并研究了RTMS/TDS/TDCS/TDCS的联合应用和重密度培训的临床效果。结果，连续应用低频RTM在非静态半球上使用强化职业治疗是安全的，并且似乎有可能改善后击中患者受影响上肢的运动功能。此外，这种组合显着降低了受影响上肢的肌肉肌肉肌肉，表明干预的抗痉挛作用。不幸的是，由于设备的意外机械故障，TDC对中风后上肢运动功能的影响尚未得到充分阐明。

项目成果

MB Medical Rehabilitation創刊10周年記念症例から学ぶ実践脳卒中リハビリテーション

MB医疗康复十周年 中风康复实践案例学习

• 发表时间: 2011
• 作者: 角田亘;安保雅博
• 通讯作者: 安保雅博

Low-frequency rTMS plus intensive occupational therapy improves motor function and reduces spasticity of paretic upper limbin post-stroke patients : A pilot study.

低频 rTMS 加上强化职业治疗可改善中风后瘫痪上肢患者的运动功能并减少痉挛：一项试点研究。

• 发表时间: 2010
• 作者: Kakuda W;Abo M;el al.
• 通讯作者: el al.

Baseline Severity of Upper Limb Hemiparesis Influences the Outcome of Low-Frequency rTMS Combined With Intensive Occupational Therapy in Patients Who Have Had a Stroke

• DOI: 10.1016/j.pmrj.2011.02.015
• 发表时间: 2011-06-01
• 期刊: PM&R
• 影响因子: 2.1
• 作者: Kakuda, Wataru;Abo, Masahiro;Tominaga, Ayumi
• 通讯作者: Tominaga, Ayumi

経頭蓋磁気刺激と集中的リハビリテーションの併用療法

经颅磁刺激与强化康复联合治疗

• 发表时间: 2011
• 作者: Kakuda W;Abo M;et al.;角田亘
• 通讯作者: 角田亘

Is the efficacy of low-frequency rTMS combined with intensive occupational therapy influenced by baseline severity of upper limb hemiparesis in post-stroke patients?

低频rTMS联合强化职业治疗的疗效是否受到卒中后患者上肢偏瘫基线严重程度的影响？

• 发表时间: 2011
• 作者: Kakuda W;Abo M;Kobayashi K;Momosaki R;Yokoi A;Fukuda A;Ito H;Tominaga A
• 通讯作者: Tominaga A