The effect of i nterleukin-17 producing CD4+ T cells (T_H-17 cells) on immune system and progression of digestive cancer.

产生白介素 17 的 CD4 T 细胞（T_H-17 细胞）对免疫系统和消化道癌症进展的影响。

• 批准号: 20591571
• 负责人: SAITO Hiroaki
• 金额: $ 3万
• 依托单位: Tottori University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591571/
• 关键词: 消化器癌; T_H-17細胞; インターロイキン17; 胃癌; ケモカイン; Tリンパ球; IL-17

In the current study, we determined the frequency of T_H-17 cells obtained from gastric cancer patients. In addition, clinical significance of IL-17 that is mainly produced by T_H-17 cells was determined in gastric cancer patients. The frequency of T_H-17 cells in the tissue of gastric cancer was significantly more than those in peripheral blood. The concentration of IL-17, hallmark of T_H-17, in gastric cancer patients was significantly higher than that in normal controls. The prognosis of gastric cancer patients with high IL-17 concentration was significantly poor than that with low IL-17 concentration. Furthermore, multivariate analysis indicated that IL-17 concentration was an independent prognostic indicator as well as lymph node metastasis was. In conclusion, T_H-17 cells may play an extremely important role in the progression of gastric cancer though the IL-17 production.

在当前的研究中，我们确定了从胃癌患者获得的T_H-17细胞的频率。此外，在胃癌患者中确定了主要由T_H-17细胞产生的IL-17的临床意义。胃癌组织中T_H-17细胞的频率明显高于外周血中的频率。在胃癌患者中，IL-17的浓度（T_H-17的标志）明显高于正常对照中的IL-17。 IL-17浓度高的胃癌患者的预后明显低于IL-17浓度较低的胃癌患者。此外，多变量分析表明，IL-17浓度是独立的预后指标以及淋巴结转移。总之，T_H-17细胞通过IL-17的产生在胃癌的进展中起着极为重要的作用。

项目成果

胃癌患者におけるTh17細胞の検討

胃癌患者Th17细胞的检查

• 发表时间: 2009
• 作者: Fujiwara T;Tsuchiya S;Sato F;Shimada Y;Tsujimoto G;Shimizu K;齊藤博昭
• 通讯作者: 齊藤博昭

胃癌患者におけるTh17細胞の臨床的意義

胃癌患者Th17细胞的临床意义

• 发表时间: 2011
• 作者: 齊藤博昭;山田敬教;木原恭一;黒田博彦;松永知之;建部茂;池口正英
• 通讯作者: 池口正英

胃癌患者におけるインターロイキン17の臨床的意義

白细胞介素17在胃癌患者中的临床意义

• 发表时间: 2010
• 作者: 齊藤博昭;山田敬教;黒田博彦;松永知之;建部茂;池口正英
• 通讯作者: 池口正英