Neural basis of social cognitive impairments in schizophrenia : neuroimaging studies using structural and functional MRI

精神分裂症社会认知障碍的神经基础：使用结构和功能MRI的神经影像学研究

• 批准号: 20591401
• 负责人: MURAI Toshiya
• 金额: $ 2.91万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591401/
• 关键词: 神経心理学; 画像診断学

Impaired social cognition in schizophrenia is considered as the core contributor in the poor psychosocial functioning of schizophrenia patients. Using structural and functional MRI, we investigated neural bases of social cognitive impairments in schizophrenia. As results, morphological and functional abnormalities in frontal, temporal, and parietal cortices as well as white matter abnormalities were found to be associated with various facets of social cognitive impairments in schizophrenia. These results give us an insight into optimal cognitive rehabilitation in schizophrenia.

精神分裂症的社会认知受损被认为是精神分裂症患者心理社会功能不良的核心贡献者。使用结构和功能性MRI，我们研究了精神分裂症中社会认知障碍的神经基础。结果，发现额，颞皮质和顶叶皮质以及白质异常的形态和功能异常与精神分裂症的社会认知障碍的各个方面有关。这些结果使我们深入了解精神分裂症的最佳认知康复。

项目成果

Regional white matter integrity reductions correlate with cortico-subcortical gray matter reductions and social cognition ability in schizophrenia.

精神分裂症患者的区域白质完整性减少与皮质-皮质下灰质减少和社会认知能力相关。

• 发表时间: 2009
• 作者: Miyata J;Hirao K;Yamada M;Namiki C;Fujiwara H;Shimizu M;Fukuyama H;Sawamoto N;Hayashi T;Murai T.
• 通讯作者: Murai T.

Female specific anterior cingulate abnormalities and empathic disabilities in schizophrenia.

精神分裂症女性特异性前扣带回异常和共情障碍。

• 发表时间: 2008
• 作者: Fujiwara H;Shimizu M;Hirao K;Miyata J;Sawamoto N;Fukuyama H;Hayashi T;Murai T.
• 通讯作者: Murai T.

Abnormal Gyrification and Brain Volume Reduction in Schizophrenia

精神分裂症的异常回旋和脑容量减少

• 发表时间: 2008
• 作者: Saze T;Hirao K;Miyata J;Fujiwara H;Shimizu M;Namiki C;Sawamoto N;Fukuyama H;Hayashi T;Murai T.
• 通讯作者: Murai T.

Reduced white matter integrity correlated with cortico-subcortcal gray matter deficits in schizophrenia

精神分裂症患者白质完整性降低与皮质-皮质下灰质缺陷相关

• 发表时间: 2009
• 期刊: Schizophrenia Research
• 影响因子: 4.5
• 作者: Miyata J;Hirao K;Namiki C;Fujiwara H;Shimizu M;Fukuyama H;Sawamoto N;Hayashi T;Murai T.
• 通讯作者: Murai T.

Investigating association of brain volumes with intracranial capacity in schizophrenia

研究精神分裂症患者脑容量与颅内容量的关系

• 发表时间: 2010
• 期刊: Neuroimage 49
• 作者: Ueda K;Fujiwara H;Miyata J;Hirao K;Saze T;Kawada R;Fujimoto S;Tanaka Y;Sawamoto N;Fukuyama H;Murai T
• 通讯作者: Murai T