Analyses on Perinatal Brain Injury on the basis of Evaluation of Fetus-Placenta System.

基于胎儿胎盘系统评价的围产期脑损伤分析。

• 批准号: 20591306
• 负责人: OKUMURA Akihisa
• 金额: $ 2.91万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591306/
• 关键词: 新生児脳障害; 胎児発育不全; RNA発現; 脂肪酸組成; トロンボキサンA2; ドコサヘキサエン酸; 脳室周囲白質軟化症; RNA発現解析; 臍帯血; リボゾーム蛋白; エリスロポエチン; アンギオテンシン変換酵素; P-セレクチン; 8-イソプロスタン

There were no significant differences in the cord blood levels of Tau protein, S-100B, 8OHdG, or MMP-9 between the preterm infants with and without periventricular leukomalacia. We examined the difference in mRNA expression in umbilical cord blood according to the presence or absence of periventricular leukomalacia. Five of the 15 up-regulated genes are coding ribosomal proteins, and another encodes a translation elongation factor. This may indicate an activation of lymphocytes during the fetal period. We examined the difference in mRNA expression in the cerebrum between fetal growth retardation model rats and control ones. Seventy-three genes were up-regulated in fetal growth retardation model rats, and 55 were down-regulated. We evaluated the effect of maternal docosahexaenoic acid-enriched diet on the brain of fetal growth retardation model rats. The percentage of docosahexaenoic acid was higher in the docosahexaenoic acid-enriched group than in the control group.

患有和不患有脑室周围白质软化的早产儿的脐带血中 Tau 蛋白、S-100B、8OHdG 或 MMP-9 水平没有显着差异。我们根据脑室周围白质软化的存在与否检查了脐带血中 mRNA 表达的差异。 15 个上调基因中有 5 个编码核糖体蛋白，另一个编码翻译延伸因子。这可能表明胎儿时期淋巴细胞的激活。我们检查了胎儿生长迟缓模型大鼠和对照大鼠大脑中 mRNA 表达的差异。胎儿生长迟缓模型大鼠中有73个基因上调，55个基因下调。我们评估了母体富含二十二碳六烯酸的饮食对胎儿生长迟缓模型大鼠大脑的影响。富含二十二碳六烯酸的组中二十二碳六烯酸的百分比高于对照组。

项目成果

Nutritional state, maturational delay on electroencephalogram, and developmental outcome in extremely low birth weight infants

• DOI: 10.1016/j.braindev.2009.09.011
• 发表时间: 2010-09-01
• 期刊: BRAIN & DEVELOPMENT
• 影响因子: 1.7
• 作者: Okumura, Akihisa;Hayakawa, Masahiro;Watanabe, Kazuyoshi
• 通讯作者: Watanabe, Kazuyoshi

小児良性部分てんかんの病態と治療:良性乳児部分てんかん

儿童良性部分性癫痫的病理学和治疗：良性婴儿部分性癫痫

• 发表时间: 2010
• 作者: Ohara H;Saito R;Hirakawa S;Shimada M;Mano N;Hishinuma T;Okuyama R;Aiba S.;Yanagihara I;奥村彰久
• 通讯作者: 奥村彰久

早産児核黄疸の1例

早产儿核黄疸一例

• 发表时间: 2010
• 作者: Vincent SD;Miyagawa-Tomita S;et al.;奥村彰久
• 通讯作者: 奥村彰久

著明な高ビリルビン血症を欠く早産児の核黄疸様症候群-診断基準案の提案-

缺乏明显高胆红素血症的早产儿核黄疸样综合征 - 诊断标准的提议 -

• 发表时间: 2008
• 作者: Okuyama R;et.al.;奥村彰久
• 通讯作者: 奥村彰久

著明な高ビリルビン血症を欠く早産児の核黄疸様症候群 -診断基準案の提案-

缺乏明显高胆红素血症的早产儿核黄疸样综合征 - 诊断标准的提议 -

• 发表时间: 2008
• 作者: 奥村彰久;城所博之;深沢達也;三牧正和;久田研;東海林宏道;清水俊明
• 通讯作者: 清水俊明