Regulation of hematopoiesis by dendritic cells

树突状细胞对造血的调节

• 批准号: 20591144
• 负责人: SAWADA Kenichi
• 金额: $ 3万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591144/
• 关键词: 樹状細胞; 造血幹細胞; 自然免疫; トール様受容体; 血球貪食症候群; トール様受容体(TLR)9; CpG-ODN 2006; 赤芽球系前駆細胞; ヒトパルボイルスB19; TLR3; poly I:C; TNF阻害剤; CpG-ODN2006; ヒトパルボウイルスB19; エリスロポエチン受容体; CD34陽性細胞; 腫瘍壊死因子; Toll様受容体; TLR9

Dendritic cells (DCs) maintain the homeostasis of immunologic system by regulating lymphocyte functions through the production of various cytokines. The collapse of this regulatory system promotes immunologic disorders such as compromised infection, overresponse to immunologic stimuli and autoimmune diseases. DCs might influence differentiation and proliferation of hematopoietic stem cells, however, a large part has remained unclear. This study, at least in part, revealed the mechanism and the physiological role of DCs phagocytosing self-hematopoietic cells and the influence of microbe-derived nucleic acid such as DNA and RNA.

树突状细胞（DC）通过产生各种细胞因子来调节淋巴细胞功能，维持免疫系统的稳态。这种调节系统的崩溃会促进免疫紊乱，例如感染受损、对免疫刺激的过度反应和自身免疫性疾病。 DCs可能影响造血干细胞的分化和增殖，但其中很大一部分仍不清楚。这项研究至少部分揭示了DC吞噬自体造血细胞的机制和生理作用以及微生物来源的核酸（例如DNA和RNA）的影响。

项目成果

CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells

• DOI: 10.1182/blood-2009-08-239202
• 发表时间: 2010-06-03
• 期刊: BLOOD
• 影响因子: 20.3
• 作者: Guo, Yong-Mei;Ishii, Keiko;Sawada, Kenichi
• 通讯作者: Sawada, Kenichi

ABCG2 C.421C>A Is Associated with Higher Trough Imatinib Plasma Levels in Patients with Chronic Myeloid Leukemia.

ABCG2 C.421C>A 与慢性粒细胞白血病患者较高的伊马替尼血浆谷水平相关。

• 发表时间: 2009
• 作者: Takahashi N;Miura M;Scott SA;Sawada K
• 通讯作者: Sawada K

Dynamics of human erythroblast enucleation

• DOI: 10.1007/s12185-008-0200-6
• 发表时间: 2008-12-01
• 期刊: INTERNATIONAL JOURNAL OF HEMATOLOGY
• 影响因子: 2.1
• 作者: Hebiguchi, Miwa;Hirokawa, Makoto;Sawada, Kenichi
• 通讯作者: Sawada, Kenichi

Monoclonal immunoglobulin deposition disease associated with Imembranous features

与膜特征相关的单克隆免疫球蛋白沉积病

• 发表时间: 2008
• 期刊: Nephrol Dial Transplant 38
• 作者: Komatsuda A;Masai R;Ohtani H;Togashi M;Maki N;Sawada K;Wakui H.
• 通讯作者: Wakui H.

Establishment of a murine hemophagocytic syndrome model by administration of CpG and Mod1 ligand.

通过给予 CpG 和 Mod1 配体建立小鼠噬血细胞综合征模型。

• 发表时间: 2010
• 作者: Ohyagi H;Onai N;Guo YM;Takahashi N;Hirokawa M;Sawada K;Ohteki T
• 通讯作者: Ohteki T