The study on the molecular relationships between TRPC6, NFκB, and NFAT in the progress of chronic kidney diseases

TRPC6、NFκB、NFAT在慢性肾脏病进展中的分子关系研究

• 批准号: 20590961
• 负责人: HAYASHI Matsuhiko
• 金额: $ 3万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590961/
• 关键词: 慢性腎臓病; NFκB; NFAT; TRPC6

To reveal the mechanisms of progression of chronic kidney diseases, the roles of TRPC6, which was reported to be a causative gene for one type of congenital focal segmental sclerosis and related some forms of renal diseases, and NFAT and NFκB, TRPC6-related signal transduction protein, were examined in the rat models of renal diseases. The inhibitor of NFκB ameliorated renal impairment by aldosterone, which is recently reported to play a role in the renal injury of chronic kidney diseases, whereas TRPC6 and NFAT did not show significant changes. In the present study, it was suggested that NFκB activation plays important roles in certain types of kidney diseases and its inhibitor may be a candidate for the treatment of chronic kidney disease.

为了揭示慢性肾脏疾病进展的机制，TRPC6的作用是一种严重的基因，对于一种先天性局灶性局灶性段落段性硬化及其相关的某些形式的肾脏疾病，NFAT和NFAT和NF-κB，TRPC6相关的信号转导蛋白，在肾脏疾病中检查了与肾脏疾病的比例模型。 NFκB的抑制剂改善了醛固酮的肾脏损伤，醛固酮最近据报道在慢性肾脏疾病的肾损伤中起作用，而TRPC6和NFAT并未显示出重大变化。在本研究中，有人提出NFκB激活在某些类型的肾脏疾病中起着重要作用，其抑制剂可能是治疗慢性肾脏疾病的候选者。

项目成果

Aldosterone-induced kidney injury is mediated by NFκB activation.

• DOI: 10.1007/s10157-010-0373-1
• 发表时间: 2011-03
• 期刊: Clinical and experimental nephrology
• 影响因子: 2.3
• 作者: Fukuda S;Horimai C;Harada K;Wakamatsu T;Fukasawa H;Muto S;Itai A;Hayashi M
• 通讯作者: Hayashi M

腎内アンジオテンシン変換酵素2型(ACE2)はアルドステロンにより抑制される

醛固酮抑制肾内血管紧张素转换酶 2 (ACE2)

• 发表时间: 2010
• 作者: 林松彦;堀米ちひろ;福田誠一;原田香織;柳瀬健志;深澤弘志;武藤進;板井昭子
• 通讯作者: 板井昭子

Inhibition of NF-kappaB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis.

簇蛋白抑制 NF-κB 依赖性 Bcl-xL 表达可促进白蛋白诱导的肾小管细胞凋亡。

• 发表时间: 2008
• 期刊: Kidney International 73
• 作者: Takase 0;Minto AW;Puri TS;Cunningham PN;Jacob A;Hayashi M;Quigg RJ.
• 通讯作者: Quigg RJ.

Angiotensin-converting enzyme 2 and clusterin are regulated by aldosterone in the kidney.

血管紧张素转换酶 2 和簇蛋白受肾脏中醛固酮的调节。

• 发表时间: 2009
• 作者: Hayashi M;Horimai C;Fukuda S;Saito N;Yanase T;Fukasawa H;Muto S;Itai A
• 通讯作者: Itai A

NFκB activation is involved in aldosterone-induced tissue injuryin the kidney but not in the heart.

NFκB 激活与醛固酮诱导的肾脏组织损伤有关，但与心脏组织损伤无关。

• 发表时间: 2008
• 作者: Hayashi M;Fukuda S;Monkawa T;Saito N;Yanase T;Fukasawa H;Muto S;Itai A;Shimoda K
• 通讯作者: Shimoda K