Chemokines in Aqueous humour before and after IntravitrealTriamcinolone Acetonide in Eyes with Macular Edema Associated with Branch Retinal VeinOcclusion

视网膜分支静脉阻塞相关黄斑水肿患者玻璃体内注射曲安奈德前后房水中的趋化因子

• 批准号: 20791243
• 负责人: KUNIKATA Hiroshi
• 金额: $ 2.58万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791243/
• 关键词: ケモカイン; 前房水; ステロイド; 黄斑浮腫; 網膜静脈分枝閉塞; MIP-1β; サイトカイン; 硝子体; トリアムシノロンアセトニド; 中心窩網膜厚; VEGF; トリアムシノロン; MIP-1b

We determined the aqueous humour levels of chemokines before and after an intravitreal injection of triamcinolone acetonide (IVTA) in eyes with macular edema associated with a branch retinal vein occlusion (ME-BRVO). At the baseline, MCP-1 and MIP-1a were detected in the aqueous, and MIP-1b was significantly higher in eyes with a ME-BRVO than in controls. One week after IVTA, the foveal thickness (FT) was significantly decreased, and the levels of MCP-1 and MIP-1b were also significantly reduced. The decrease in the FT was correlated with the decrease of only MIP-1b. This indicates that the steroid-dependent ME-BRVO was closely related with the level of MIP-1b.

我们确定了玻璃体内注射前后的趋化水平的趋化因子在眼睛的眼睛中，具有与分支视网膜静脉闭塞（ME-BRVO）相关的黄斑水肿的眼睛中。在基线时，在水性中检测到MCP-1和MIP-1A，而ME-BRVO的眼睛中的MIP-1B明显高于对照组。 IVTA后一周，中央凹厚度（FT）显着降低，MCP-1和MIP-1B的水平也显着降低。 FT的减少与仅MIP-1B的减少相关。这表明依赖类固醇的ME-BRVO与MIP-1B的水平密切相关。

项目成果

Central retinal artery occlusion following severe blow-out fracture in young adult

年轻成人严重爆裂性骨折后视网膜中央动脉闭塞

• 发表时间: 2009
• 期刊: Clin Ophthalmol 3
• 作者: Himori N;Kunikata H;Otomo T;Fuse N;Nishida K.
• 通讯作者: Nishida K.

Visual outcome and complications of 25-gauge vitrectomy for rheamatogenous retinal detachment ; Eighty-four consecutive cases

25 号玻璃体切除术治疗血源性视网膜脱离的视力结果和并发症；

• 发表时间: 2010
• 期刊: Eye (In press)
• 作者: Kunikata H;Nishida K.
• 通讯作者: Nishida K.

Central Retinal Artery Occlusion followingSevere Blow-out Fracture in Young Adult

年轻成人严重爆裂性骨折后视网膜中央动脉闭塞

• 发表时间: 2009
• 期刊: Clin Ophthalmol (In press)
• 作者: Himori N;Kunikata K;Otomo T;MD. Fuse N and Nishida K
• 通讯作者: MD. Fuse N and Nishida K

Chemokines in Aqueous humour before and after Intravitreal Triamcinolone Acetonide in Eyes with Macular Edema Associated with Branch Retinal Vein Occlusion

视网膜分支静脉阻塞相关黄斑水肿患者玻璃体内注射曲安奈德前后房水中的趋化因子

• 发表时间: 2010
• 期刊: Acta Ophthalmologica (In press)
• 作者: Kunikata H;Shimura M;Nakazawa T;Sonoda K;Yoshimura T;Ishibashi T;Nishida K.
• 通讯作者: Nishida K.

25ゲージ硝子体手術後の重篤な脈絡膜剥離

25 号玻璃体切除术后严重脉络膜脱离

• 发表时间: 2008
• 作者: 國方彦志;高橋秀肇;中村政彦;西田幸二
• 通讯作者: 西田幸二