Analysis of induction mechanisms for tumor antigen-specific regulatory T cells in lymphoma

淋巴瘤肿瘤抗原特异性调节性T细胞诱导机制分析

• 批准号: 20790681
• 负责人: MATSUSHITA Maiko
• 金额: $ 2.66万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790681/
• 关键词: 悪性リンパ腫; 制御性T細胞; がん抗原; 腫瘍抗原

To analyze the development mechanisms of regulatory T (Treg) cells in B cell lymphoma patients, we established a model system using 5C.C7 TCR-Tg/RAG^<-/-> mice and B cell lymphoma cells expressing antigen peptides with various TCR affinities and expression levels. We showed that intrathymically-injected agonistic antigen peptides could induce Treg cells in peripheral lymphoid tissues with high efficiency.

为了分析B细胞淋巴瘤患者调节性T（Treg）细胞的发育机制，我们使用5C.C7 TCR-Tg/RAG^<-/->小鼠和表达具有各种TCR的抗原肽的B细胞淋巴瘤细胞建立了模型系统亲和力和表达水平。我们发现胸腺内注射的激动性抗原肽可以高效诱导外周淋巴组织中的 Treg 细胞。

项目成果

Chimeric Antigen Receptors Combining 4-1BB and CD28 Signaling Domains Augment PI3kinase/AKT/Bcl-XL Activation and CD8+ T Cell-mediated Tumor Eradication

• DOI: 10.1038/mt.2009.210
• 发表时间: 2010-02-01
• 期刊: MOLECULAR THERAPY
• 影响因子: 12.4
• 作者: Zhong, Xiao-Song;Matsushita, Maiko;Sadelain, Michel
• 通讯作者: Sadelain, Michel