Relationship between the adverse effect of kampo medicine and transporters

汉方药不良反应与转运蛋白的关系

• 批准号: 20790475
• 负责人: MAKINO Toshiaki
• 金额: $ 2.75万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790475/
• 关键词: 東洋医学; 甘草; 偽アルドステロン症; 有機アニオントランスポーター; グリチルリチン酸; ヒドロキンステロイド脱水素酵素; グリチルレチン酸; 漢方薬; 副作用; ヒドロキシステロイド脱水素酵素

Glycyrrhizae Radix has the adverse effect to cause pseudoaldosteronism. It is considered that pseudoaldosteronism is induced by glycyrrhitinic acid (GA) that inhibits 11β-hydroxysteroid dehydrogenase II in renal tubular epithelial cells. The present study reveals that GA cannot pass through the membrane of epithelial cells, but 3-monoglucuronyl glycyrrhietinic acid (3MGA) can actively be transported through the membrane by orgaic anion transporters. It is suggested that the adverse effect of licorice would be occurred not by GA but 3MGA.

甘草具有引起假性醛固酮增多症的不良作用，认为假性醛固酮增多症是由甘草次酸(GA)抑制肾小管上皮细胞内的11β-羟基类固醇脱氢酶II引起的。目前的研究表明，GA不能穿过上皮细胞膜。 ，但 3-单葡萄糖醛酸甘草次酸 (3MGA) 可以通过膜主动转运表明甘草的不良作用不是由GA而是由3MGA引起。

项目成果

Down-regulation of a hepatic transporter Mrp2 is involved in alteration of pharmacokinetics of glycyrrhizin and its metabolites in a rat model of chronic liver injury.

肝脏转运蛋白 Mrp2 的下调参与慢性肝损伤大鼠模型中甘草酸及其代谢物的药代动力学改变。

• 发表时间: 2008
• 期刊: Drug Metab. Dispos. 36(7)
• 作者: Toshiaki Makino;Nobuhiro Ohtake;Akito Watanabe;Naoko Tsuchiya;Sachiko Imamura;Seiichi Iizuka;Makoto Inoue;Hajime Mizukami.
• 通讯作者: Hajime Mizukami.

グリチルリチンおよびその代謝物の腎における11 β-HSD II阻害作用の比較

甘草甜素及其代谢物对肾11β-HSD II抑制作用的比较

• 发表时间: 2009
• 作者: 上林理絵;牧野利明;井上勝央;水上元;大嶽信弘
• 通讯作者: 大嶽信弘

Down-regulation of a hepatic transporter multidrug resistance-associated protein 2 is involved in alteration of pharmacokinetics of glycyrrhizin and its metabolites in a rat model of chronic liver injury

• DOI: 10.1124/dmd.108.021089
• 发表时间: 2008-07-01
• 期刊: DRUG METABOLISM AND DISPOSITION
• 影响因子: 3.9
• 作者: Makino, Toshiaki;Ohtake, Nobuhiro;Mizukami, Hajime
• 通讯作者: Mizukami, Hajime

グリチルリチンおよびその代謝物の腎における11β-HSD II阻害作用の比較

甘草甜素及其代谢物对肾11β-HSD II抑制作用的比较

• 发表时间: 2010
• 作者: 上林理絵;牧野利明;井上勝央;水上元;大嶽信弘
• 通讯作者: 大嶽信弘