Molecular Basis of the regulation of ETS transcription factor MEF expression by tumor suppressor gene p53

抑癌基因p53调控ETS转录因子MEF表达的分子基础

• 批准号: 20790068
• 负责人: ANN SOTEN Suico mary
• 金额: $ 2.75万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790068/
• 关键词: 薬理学; MEF; ETS; p53; E2F; p21; Myeloid elf-1 like factor (MEF); Sp1; E2F1; プロモーター; 転写; Meloid elf-1 like factor(MEF)

MEF is one of the ETS transcription factors which regulates a diverse range of innate immune molecules including antibacterial peptides, cytokines and innate immune cell progression. In the present study, we investigated the role of tumor suppressor gene p53 in the regulation of MEF expression. We demonstrate that p53 directly binds to E2F1 and inhibits E2F1 binding to MEF promoter, thereby suppressing MEF transcription.

MEF 是 ETS 转录因子之一，调节多种先天免疫分子，包括抗菌肽、细胞因子和先天免疫细胞进展。在本研究中，我们研究了抑癌基因p53在MEF表达调节中的作用。我们证明p53直接与E2F1结合并抑制E2F1与MEF启动子的结合，从而抑制MEF转录。

项目成果

Role of calnexin in the ER quality control and productive folding of CFTR; differential effect of calnexin knockout on wild-type and DF508 CFTR. Biochem

钙联蛋白在 ER 质量控制和 CFTR 有效折叠中的作用；

• 发表时间: 2008
• 期刊: Biochim. Acta (Mol. Cell Res. ) 1783
• 作者: Okiyoneda T.;Niibori A.;Harada K.;Kohno T.;Michalak M.;Duszyk M.;Wada I.;Ikawa M.;Shuto T.;Suico M. A;Kai H.
• 通讯作者: Kai H.

Calreticulin positively regulates the expression and function of epithelial sodium channel

• DOI: 10.1016/j.yexcr.2009.09.023
• 发表时间: 2009-11-15
• 期刊: EXPERIMENTAL CELL RESEARCH
• 影响因子: 3.7
• 作者: Sugahara, Takuya;Koga, Tomoaki;Kai, Hirofumi
• 通讯作者: Kai, Hirofumi

The expression of antimicrobial peptide lysozyme is increased by treatment

治疗后抗菌肽溶菌酶的表达增加

• 发表时间: 2009
• 期刊: J. Health Sci. 55
• 作者: Mary Ann Suico;Atsushi Tanaka;Tsuyoshi Shuto;Hirofumi Kai
• 通讯作者: Hirofumi Kai

Mild Electrical Stimulation Increases Ubiquitinated Proteins and Hsp72 in A549 Cells via Attenuation of Proteasomal Degredation

轻度电刺激通过减弱蛋白酶体降解增加 A549 细胞中的泛素化蛋白和 Hsp72

• 发表时间: 2008
• 期刊: J Pharmacol Sci. 108
• 作者: Saori Morino;Mary Ann Suico;Tatsuya Kondo;Erika Sekimoto;Shuichiro Yano. Tomoko Matsuda;Takashi Matsuno;Tsuyoshi Shuto;Eiichi Araki;Hirohumi Kai
• 通讯作者: Hirohumi Kai

Multi-elemental analysis of serum and amyloid fibrils in familial amyloid polyneuropathy patients

家族性淀粉样多发性神经病患者血清和淀粉样原纤维的多元素分析

• 发表时间: 2008
• 期刊: Amyloid (The Journal of Protein FOlding Disorders) 15(2)
• 作者: Susuki S;et.al.
• 通讯作者: et.al.