Identification and characterization of proteins bound to MURC which is involved in cardiac dysfunction and arrhythmia

与心功能障碍和心律失常相关的 MURC 结合蛋白的鉴定和表征

• 批准号: 20590863
• 负责人: UEYAMA Tomomi
• 金额: $ 3万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590863/
• 关键词: 心不全; 不整脈; 筋特異的遺伝子; 結合蛋白質; MURC

We found that MURC was localized to caveolae at the plasma membrane of cardiomyocytes, and that MURC was associated with caveolin-3, PTRF/cavin-1, SDPR/cavin-2, and SRBC/cavin-3. We also found that overexpression of MURC in cardiomyocytes induced distension of caveolae and transgenic mice expressing MURC in the heart exhibited deformation of caveolae in cardiomyocytes.

我们发现 MURC 定位于心肌细胞质膜的小窝，并且 MURC 与 Caveolin-3、PTRF/cavin-1、SDPR/cavin-2 和 SRBC/cavin-3 相关。我们还发现，心肌细胞中MURC的过度表达引起小窝扩张，并且在心脏中表达MURC的转基因小鼠表现出心肌细胞小窝变形。

项目成果

A novel but evolutionarily conserved muscle-restricted coiled-coil protein, MURC, regulates myogenic differentiation in C2C12 cells.

MURC 是一种新型但进化上保守的肌肉限制性卷曲螺旋蛋白，可调节 C2C12 细胞的肌原性分化。

• 发表时间: 2008
• 作者: Tagawa M;Ueyama T;Ogata T;Nakajima N;Isodono K;Asada S;Takehara N;Takahashi T;Matsubara Hiroaki;Oh H.
• 通讯作者: Oh H.

MURC, Muscle-restricted coiled-coil protein, regulates caveolae morphology and induces hypertrophy in cardiomyocytes.

MURC，肌肉限制性卷曲螺旋蛋白，调节小凹形态并诱导心肌细胞肥大。

• 发表时间: 2010
• 作者: Taniguchi T;Ogata T;Naito D;Nakanishi N;Miyagawa K;Amano K;Isodono K;Imoto H;Tagawa M;Takehara N;Asada S;Adachi A;Morimoto M;Takahashi T;Oh H;Ueyama T;Matsubara H.
• 通讯作者: Matsubara H.

Role of endothelial lipase in plasma HDL levels in a murine model of hypertriglyceridemia.

内皮脂肪酶在高甘油三酯血症小鼠模型血浆高密度脂蛋白水平中的作用。

• 发表时间: 2009
• 期刊: J Atheroscler Thromb 16
• 作者: Tanaka H;et al.
• 通讯作者: et al.

PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes.

• DOI: 10.1371/journal.pone.0009746
• 发表时间: 2010-03-18
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Isodono K;Takahashi T;Imoto H;Nakanishi N;Ogata T;Asada S;Adachi A;Ueyama T;Oh H;Matsubara H
• 通讯作者: Matsubara H

Serglycin, a novel adipokine highly expressed in epicardial adipose tissue.

Serglycin，一种在心外膜脂肪组织中高表达的新型脂肪因子。

• 发表时间: 2010
• 作者: Imoto H;Takahashi T;Adachi A;Nakanishi N;Kangawa H;Ueyama T;Matsubara H
• 通讯作者: Matsubara H