Role and mechanism of thrombospondin in response to beta blocker therapy in patients with congestive heart failure

血小板反应蛋白在充血性心力衰竭患者β受体阻滞剂治疗中的作用和机制

• 批准号: 20590834
• 负责人: TAKEMOTO Yasuhiko
• 金额: $ 2.83万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590834/
• 关键词: 薬剤応答性; 循環器・高血圧; 薬理学; 臨床; 内科; 慢性心不全; アドレナリンβ受容体遮断薬; 血管内皮機能; 左室収縮能; 遺伝子多型; 拡張型心筋症; トロンボスポンジン; 薬剤反応性; 血管内皮機能改善; 左室収縮能改善

We evaluated Ala523Thr polymorphism(G/A) and thrombospondin-1 plasma levels in nonischemic congestive heart failure patients before, 6, and 12 months after administration of beta blocker therapy and in normal healthy volunteers. There were no significant differences of thrombospondin-1 plasma levels between GG group and non GG group in normal healthy volunteers. No significant differences of thrombospondin-1 plasma levels were found between GG group and non GG group in nonischemic congestive heart failure patients. There were significant correlations between changes in BNP levels from before to 12 months after administration of beta blocker therapy and those in plasma thrombospondin-1 levels. Thrombospondin-1 may play a role in hemodynamic optimization at the chronic stage of nonischemic congestive heart failure.

我们评估了非缺血性充血性心力衰竭患者在接受β受体阻滞剂治疗前、6个月和12个月以及正常健康志愿者中的Ala523Thr多态性（G/A）和血小板反应蛋白-1血浆水平。正常健康志愿者中GG组与非GG组血浆血小板反应蛋白1水平无显着差异。非缺血性充血性心力衰竭患者GG组与非GG组血浆血小板反应蛋白1水平无显着差异。 β受体阻滞剂治疗前至治疗后12个月期间BNP水平的变化与血浆血小板反应蛋白-1水平的变化之间存在显着相关性。 Thrombospondin-1 可能在非缺血性充血性心力衰竭慢性阶段的血流动力学优化中发挥作用。

项目成果

Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients

• DOI: 10.1007/s00228-009-0685-9
• 发表时间: 2009-11-01
• 期刊: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
• 影响因子: 2.9
• 作者: Ohno, Masako;Yamamoto, Akiko;Azuma, Junichi
• 通讯作者: Azuma, Junichi

Multiple cardiac thrombi and thromboembolism in a heparin-induced thrombocytopenia antibody-positive patient with heart failure

肝素诱导血小板减少抗体阳性心力衰竭患者多发性心脏血栓和血栓栓塞

• 发表时间: 2008
• 期刊: Am J Emerg Med 9
• 作者: Ikejima H;Imanishi T;et al.;Ryotaro Wake
• 通讯作者: Ryotaro Wake

本邦における未治療重症大動脈弁狭窄患者の検討

日本未经治疗的严重主动脉瓣狭窄患者的研究

• 发表时间: 2009
• 作者: Tanaka F;Makita S;Onoda T;Tanno K;Ohsawa M;Itai K;Sakata K;Onodera M;Koeda Y;Kawarura K;Terayama Y;Yoshida Y;Ogawa A;Okayama A;Nakamura M;和田諭子
• 通讯作者: 和田諭子

加速ベッドが冠微少循環に与える影響

加速床对冠脉微循环的影响

• 发表时间: 2009
• 作者: Nishikimi T;他2名;河野靖
• 通讯作者: 河野靖

心不全におけるβ受容体遮断薬反応性個体差の究明 : 良好反応性関連因子の検討

心力衰竭患者β受体阻滞剂反应性个体差异的调查：检查与良好反应性相关的因素

• 发表时间: 2008
• 作者: Ohsawa M;Itai K;Onoda T;Tanno K;Sasaki S;Nakamura M;Ogawa A;Sakata K;Kawamura K;Kuribayashi T;Yoshida Y;Okayama A.;河野靖
• 通讯作者: 河野靖