Studies on the Bioactivity and Intensive Use of the Constituents of Azadirachta indica (Neem)

印楝成分的生物活性及集约利用研究

• 批准号: 20590015
• 负责人: AKIHISA Toshihiro
• 金额: $ 3.08万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590015/
• 关键词: ニーム; リモノイド; メラニン産生抑制; 抗腫瘍活性; 発がん予防効果; ニーム; リモノイド; メラニン産生抑制; 抗腫瘍活性; 発がん予防効果

Thirty-one limonoids and one diterpenoid, and seventeen limonoids were isolated from the methanol and hexane extracts, respectively, of neem seeds. Among these compounds, seven were new compounds, and their structures were determined spectroscopically. These compounds were evaluated for their melanogenesis-inhibitory, anti-inflammatory, Epstein-Barr virus early antigen (EBV-EA) activation inhibitory, and cytotoxic activities. Some of these compounds have been revealed to possess potent melanogenesis-inhibitory, anti-inflammatory, EBV-EA activation inhibitory, and cytotoxic activities with apoptosis induction.

分别从印em种子的甲醇和己烷提取物中分离出31一种和1个二萜类化合物和17个柠檬叶。在这些化合物中，七种是新化合物，它们的结构是通过光谱确定的。评估了这些化合物的黑色素发生抑制作用，抗炎，爱泼斯坦 - 巴尔病毒早期抗原（EBV-EA）激活抑制和细胞毒性活性。这些化合物中的一些已揭示具有有效的抑制黑色素发生，抗炎，EBV-EA激活抑制性和凋亡诱导的细胞毒性活性。