The mechanism of gonadal sex determination in avian embryo

禽类胚胎性腺性别决定机制

• 批准号: 20570203
• 负责人: YOSHIOKA Hidefumi
• 金额: $ 3.24万
• 依托单位: Hyogo University of Teacher Education
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20570203/
• 关键词: 生殖腺; 性分化; ニワトリ胚; 性決定遺伝子; HINTW; HINTZ; DMRT1; MHM; DM domain; chick; gonad; sex determination; ZZ; ZW; 精巣; 卵巣; 鳥類; HINT-W; HINT-Z; FET-1; W性染色体; 生殖腺; 性分化; ニワトリ胚; 性決定遺伝子; HINTW; HINTZ; DMRT1; MHM; DM domain; chick; gonad; sex determination; ZZ; ZW; 精巣; 卵巣; 鳥類; HINT-W; HINT-Z; FET-1; W性染色体

Sex in birds is chromosomally based, as in mammals, but the sex chromosomes are different and the mechanism of avian sex determination has been unknown. In birds, the homogametic sex is male (ZZ) and the hetero-gametic sex is female (ZW). Two hypotheses have been proposed for the mechanism of avian sex determination. The W (female) chromosome may carry a dominant-acting ovary determinant. Alternatively, the dosage of a Z-linked gene may mediate sex determination, two doses being required for male development (ZZ). Recently it is reported that a Z-linked gene DMRT1 is required for male sex determination in the chicken. However, another candidate genes are remained to elucidate. Hear we show that HINTW, which encodes an aberrant nucleotide hydrolase enzyme, is the candidate ovary-determinant on the W chromosome and HINTZ, which encodes a bona fide nucleotide hydrolase enzyme, a Z-linked gene, are also required for sex determination.

鸟类中的性别是基于染色体的，就像在哺乳动物中一样，但是性染色体是不同的，禽类性确定的机制尚不清楚。在鸟类中，同质性别是男性（ZZ），异性恋性是女性（ZW）。已经提出了两个假设，以实现鸟类性别确定的机制。 W（雌性）染色体可能具有占主导作用的卵巢决定因素。或者，Z连锁基因的剂量可能介导性别确定，男性发育需要两次剂量（ZZ）。最近据报道，鸡肉中的男性性别确定需要一个Z连锁的基因DMRT1。但是，另一个候选基因仍阐明。听到我们表明，编码异常核苷酸水解酶的HINTW是W染色体和Hintz上的候选卵巢确定剂，它也需要进行性别确定，它编码了一个真正的核苷酸水解酶，Z-Linked的基因。