Sjogren's Syndrome in patients with HTLV-I-associated myelopathy(HAM) :

HTLV-I 相关脊髓病 (HAM) 患者的干燥综合征：

基本信息

批准号：
11671872
负责人：
IZUMI Masahiro
金额：
$ 2.18万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671872/
关键词：
HAM Salivary gland dry mouth HTLV-1 MRI Sjogren's syndrome MR1 HTLV-1

项目摘要

Objective.To characterize imaging features of the major salivary glands in patients with HTLV-I-associated myelopathy(HAM) who were associated with Sjogren's syndrome, and to compare these features with those in HAM-negative patients with Sjogren's syndrome. Subjects and Methods. The study propulation included 31 HAM patients(12 were associated with Sjogren's syndrome), 15 HTLV-I-seropositive/HAM-negative patients with Sjogren's syndrome, and 41 HTLV-I-seronegative patients with Sjogren's syndrome. Separate 20 HAM-negative patients with sicca syndrome only were also studied. Diagnostic imaging(sialography, MR imaging, and sonography) of the salivary glands. labial gland biopsy, Schirmer test, Saxon test and serological tests were performed on these patients. Results. The parotid and submandibular glands in 11(92%) of the 12 HAM patients with Sjogren's syndrome completely lacked the abnormal imaging features characteristic of the disease, while they displayed decreased salivary flow rates at levels similar to those in the HAM-negative patients with Sjogren's Syndrome. The labial glands from the HAM patients with Sjogren's syndrome exhibited significantly lower magnitudes of mononuclear cell aggregation compared with those in the HAM-negative patients with Sjogren's syndrome. In contrast, all HAM-negative patients with Sjogren's syndrome showed abnormal imaging features characteristic of the disease, and the severity in salivary dysfunction correlated well with the imaging findings.Conclusion. These results suggest that Sjogren's syndrome in HAM patients may at least in part occur via a distinctive mechanism from classical Sjogren's syndrome in HAM-negative patients.

目的：探讨伴有干燥综合征的HTLV-I相关性脊髓病（HAM）患者主要唾液腺的影像学特征，并与HAM阴性干燥综合征患者进行比较。主题和方法。该研究包括 31 名 HAM 患者（其中 12 名与干燥综合征相关）、15 名 HTLV-I 血清阳性/HAM 阴性的干燥综合征患者和 41 名 HTLV-I 血清阴性的干燥综合征患者。还对 20 名仅患有干燥综合征的 HAM 阴性患者进行了研究。唾液腺诊断成像（唾液造影、磁共振成像和超声检查）。对这些患者进行了唇腺活检、Schirmer试验、Saxon试验和血清学试验。结果。 12 例 HAM 干燥综合征患者中，有 11 例（92%）的腮腺和颌下腺完全缺乏该疾病特征的异常影像学特征，但唾液流量降低，水平与 HAM 阴性干燥综合征患者相似。综合症。与HAM阴性干燥综合征患者相比，HAM干燥综合征患者的唇腺表现出明显较低的单核细胞聚集程度。相比之下，所有HAM阴性的干燥综合征患者均表现出疾病特有的异常影像学特征，唾液功能障碍的严重程度与影像学表现密切相关。结论。这些结果表明，HAM 患者中的干燥综合征可能至少部分通过与 HAM 阴性患者中的经典干燥综合征不同的机制发生。