The Effects of Zolpidem and Triazolam, Rilmazafone Hydrochloride on The Physical and Cognitive Functions in Healthy, Elderly Persons

唑吡坦和三唑仑、盐酸利马扎丰对健康老年人身体和认知功能的影响

• 批准号: 20500438
• 负责人: ITO Sachiko
• 金额: $ 3.16万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500438/
• 关键词: 薬剤反応性; 臨床; 脳・神経; 老化; 医療・福祉

Many problems have been reported on the use of hypnotics on the elderly, such as balance disorders, falling, and memory disorders. A safer use of hypnotics is being anticipated. We investigate the effects of a single dose of Zolpidem and Triazolam, Rilmazafone hydrochloride on the physical and cognitive function in healthy, elderly persons. We performed a double-blind crossover trial on 14 healthy elderly subjects (mean age 64.5 years) in order to investigate the residual effect of a single administration of Zolpidem (5mg) and Triazolam(0.125g), Rilmazafone hydrochloride(1mg). The subjects were given either hypnotics or a placebo at 11PM before going to bed. Objective assessments were conducted at 10PM before the subjects took the hypnotic, and at 4, 6, 10AM and 2PM the next day.The result of the Total Sway Pass was that Rilmazafone was significantly better than those of the placebo. However the results of Rilmazafone was not as good for the CFF and TUG, memory test than those of place … More bo and Zolpidem. The FRT results of Zolpidem and Triazolam were significantly better than those of the placebo. Triazolam showed little effect on the cognitive functions and the sleepiness of the subjects the day after hypnotic administration.It is known that clinical parameters which focus on the 'dynamic balance' are more useful than those which focus on 'statistic balance' in order to evaluate the accidental falls in the elderly. This study suggests that Rilmazafone hydrochloride may increase the risk of falling down because both hypnotics cause the lost of 'dynamic balance'.However, the feeling of Rilmazafone medication was not good for subjective feelings than that of a placebo. These effects may be due to Rilmazafone hydrochloride's long half- life. Therefore, subjects feel sleepiness early the next morning. It may have a good affect for the people who have interrupted sleep and early morning awakenings. Zolpidem and Triazolam have a hypnotic activity without disturbing objective and subjective performance on the following day when given to healthy elders. Less

据报道，老年人使用安眠药会出现许多问题，例如平衡障碍、跌倒和记忆障碍，我们正在研究单剂量唑吡坦和三唑仑、盐酸利马扎丰对安眠药的影响。我们对 14 名健康老年人（平均年龄 64.5 岁）进行了一项双盲交叉试验，以研究单次给药的残留效应。唑吡坦（5mg）和三唑仑（0.125g）、盐酸利马扎丰（1mg）在晚上11点睡前给予受试者催眠药或安慰剂，在受试者服用催眠药之前的晚上10点和下午4点进行客观评估。 6、第二天上午 10 点和下午 2 点。Total Sway Pass 的结果是 Rilmazafone 明显优于然而，利马扎丰的 CFF 和 TUG 记忆测试结果不如安慰剂和唑吡坦。唑吡坦和三唑仑的 FRT 结果明显好于安慰剂。众所周知，关注“动态平衡”的临床参数比关注“统计平衡”的临床参数更有助于评估这项研究表明，盐酸利马扎丰可能会增加跌倒的风险，因为这两种催眠药都会导致“动态平衡”的丧失。然而，利马扎丰用药的感觉并不比安慰剂好。这些作用可能是由于盐酸利马扎丰的半衰期较长，因此，受试者在第二天早上会感到困倦，这对于睡眠中断和清晨的人可能有良好的影响。唑吡坦和三唑仑对健康老年人具有催眠作用，不会干扰第二天的客观和主观表现。

项目成果

The Effects of Zolpidem on Phychomotor and Subjective Evaluation in Healty Elderly Persons.

唑吡坦对健康老年人运动运动和主观评价的影响。

• 发表时间: 2009
• 期刊: SLEEP32
• 作者: Ito S U;Wakasa M;Osawa Y;Shimizu K;Ito W;Aizawa R;Satake M;Shindo S;Kanbayashi T;Shimizu T
• 通讯作者: Shimizu T

The Assessment of Physical Motor Functions And Arousal Level After Awakening From An Early Morning 4:00 Till Afternoon 14:00.

清晨 4:00 至下午 14:00 醒来后身体运动功能和唤醒水平的评估。

• 发表时间: 2010
• 期刊: SLEEP
• 影响因子: 5.6
• 作者: Wakasa M;Ito S U;Kanbayashi T;et.al
• 通讯作者: et.al

The Effects of Zolpidem on Psychomotor and Subjective Evaluation in Healthy Elderly Persons.

唑吡坦对健康老年人精神运动和主观评价的影响。

• 发表时间: 2009
• 期刊: SLEEP 32
• 作者: Ito S U;Kanbayashi T;et.al
• 通讯作者: et.al

The Effects of Zolpidem and Triazolam, Rilmazafone Hydrochloride on The Physical and Cognitive Functions in Healthy, Elderly Persons.

唑吡坦和三唑仑、盐酸利马扎丰对健康老年人身体和认知功能的影响。

• 发表时间: 2010
• 期刊: SLEEP33
• 作者: Ito S U;Kanbayashi T;et.al
• 通讯作者: et.al

早朝起床直後における覚醒度と身体運動機能評価

清晨醒来后立即进行觉醒水平和身体运动功能评估

• 发表时间: 2011
• 期刊: 総合リハ 39(5)
• 作者: 若狭正彦;上村佐知子;大澤諭樹彦;佐々木誠
• 通讯作者: 佐々木誠