Surveillance of current incidence and infrastructure development of international collaboration for childhood liver cancers by Japanese study group for pediatric liver tumor

日本小儿肝脏肿瘤研究小组对儿童肝癌当前发病率和国际合作基础设施发展的监测

• 批准号: 20406028
• 负责人: HIYAMA Eiso
• 金额: $ 10.73万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20406028/
• 关键词: 癌; 医療・福祉; 薬剤反応性; トランスレーショナルリサーチ; 外科; 小児; 肝; リスク分類; 国際共同研究; 副作用; 小児肝がん; 肝芽腫; 国際共同臨床試験; 共通登録システム; 治療効果判定; 共通データベース; 副作用評価

We conducted overseas research, mainly in Europe (SIOPEL) and North America(COG), on cases of hepatoblastoma, which account for over 80% of all pediatric liver tumors.. In Japan, the rate of incidence was higher than in these countries, but the incidence of pathologically small undifferentiated tumors was lower.. According to the outcome of the patients, we stratified the hepatoblastoma patients into three risk groups : standard, intermediate, and high risks and proposed new treatment protocols for each group. We also built a new pathological classification scheme and registration database, to pave the way for international collaboration in infrastructure development for clinical trials.

我们对肝母细胞瘤的病例进行了海外研究，主要是在欧洲（Siopel）和北美（COG）（COG），占所有儿科肝肿瘤的80％以上。在日本，在日本，发病率高于这些国家的发病率，但在病理上较小的肿瘤的发病率较低，但根据患者的病情较低。每个组的高风险和提议的新治疗方案。我们还建立了一种新的病理分类计划和注册数据库，为临床试验基础设施开发方面的国际合作铺平了道路。

项目成果

Usefulness of Human Telomerase Reverse Transcriptase in Pancreatic Juice as a Biomarker of Pancreatic Malignancy

• DOI: 10.1097/mpa.0b013e3181a16d28
• 发表时间: 2009-07-01
• 期刊: PANCREAS
• 影响因子: 2.9
• 作者: Nakashima, Akira;Murakami, Yoshiaki;Hiyama, Eiso
• 通讯作者: Hiyama, Eiso

Telomere-Maintenance Mechanisms in Soft-Tissue Malignant Fibrous Histiocytomas

• DOI: 10.2106/jbjs.g.01390
• 发表时间: 2009-04-01
• 期刊: JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
• 影响因子: 5.3
• 作者: Matsuo, Toshihiro;Shay, Jerry W.;Ochi, Mitsuo
• 通讯作者: Ochi, Mitsuo

Genome-Wide Analysis of Allelic Imbalances Reveals 4q Deletions as a Poor Prognostic Factor and MDM4 Amplification at 1q32.1 in Hepatoblastoma

• DOI: 10.1002/gcc.20770
• 发表时间: 2010-07-01
• 期刊: GENES CHROMOSOMES & CANCER
• 影响因子: 3.7
• 作者: Arai, Yasuhito;Honda, Shohei;Kaneko, Yasuhiko
• 通讯作者: Kaneko, Yasuhiko

Impact of intratumoral thymidylate synthase expression on prognosis after surgical resection for ampullary carcinoma

瘤内胸苷酸合酶表达对壶腹癌术后预后的影响

• DOI: 10.1002/jso.21879
• 发表时间: 2011
• 期刊: orld Journal of Surgical Oncology
• 作者: Kato Y;Murakami Y;Uemura K;Sudo T;Hashimoto Y;Hiyama E;Sueda T
• 通讯作者: Sueda T

Changes in the agr Locus Affect Enteritis Caused by Methicillin-Resistant Staphylococcus aureus

• DOI: 10.1128/jcm.01497-08
• 发表时间: 2009-05-01
• 期刊: JOURNAL OF CLINICAL MICROBIOLOGY
• 影响因子: 9.4
• 作者: Sugiyama, Yoichi;Okii, Kazuya;Hiyama, Eiso
• 通讯作者: Hiyama, Eiso