The mechanism and function of astrocytes in ischemic spinal cord injury in rabbit

星形胶质细胞在兔缺血性脊髓损伤中的机制及功能

• 批准号: 20390362
• 负责人: WAKASA Satoru
• 金额: $ 3.41万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390362/
• 关键词: 脊髄虚血再潅流障害; 活性化グリア細胞; 遅延性脊髄障害; 細胞膜リン脂質; 質量顕微鏡; 脊髄虚血再灌流障害; アポトーシス

Spinal cord injury is one of the disastrous complications after surgical repair of thoracoabdominal aortic aneurysm and remains to be eliminated. We investigated the role of astrocytes in the spinal cord injury after transient spinal cord ischemia to elucidate whether the astrocyte would be a target for prevention of spinal cord injury. In the rabbit model, we demonstrated the significant inverse correlation between the activity of astrocytes and number of intact motor neurons. Furthermore, a concentration of arachidonic adid significantly correlated with the activity of astrocytes.

脊髓损伤是胸腹主动脉瘤手术修复后的灾难性并发症之一，仍有待消除。我们研究了星形胶质细胞在短暂性脊髓缺血后脊髓损伤中的作用，以阐明星形胶质细胞是否可以成为预防脊髓损伤的目标。在兔子模型中，我们证明了星形胶质细胞的活性与完整运动神经元的数量之间存在显着的负相关。此外，花生四烯酸的浓度与星形胶质细胞的活性显着相关。

项目成果

A semiguantitative analysis of reactive astrogliosis demonstrates its correlation with the number of intact motor neurons after transient spinal cord ischemia.

反应性星形胶质细胞增生的半定量分析表明，其与短暂脊髓缺血后完整运动神经元的数量相关。

• 发表时间: 2009
• 期刊: Journal of thoracic and cardiovascular surgery
• 影响因子: 6
• 作者: Wakasa S;Shiiya N;Tachibana T;Ooka T;Matsui Y.
• 通讯作者: Matsui Y.

ウサギ脊髄虚血再灌流モデルにおけるastrocyte活性化と遅発性運動神経細胞死に関する検討

兔脊髓缺血再灌注模型中星形胶质细胞活化和迟发性运动神经元死亡的研究

• 发表时间: 2008
• 作者: Gu Z;Mitsui H;lnomata K;Honda M;Endo C;Sakurada A;Sato M;Okada Y;Kondo T;Horii A;田坂健彦;若狭哲
• 通讯作者: 若狭哲