A disease spectrum induced by EB virus latent infections and the pathogenesis

EB病毒潜伏感染引起的疾病谱及其发病机制

• 批准号: 20390307
• 负责人: IWATSUKI Keiji
• 金额: $ 12.06万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390307/
• 关键词: 種痘様水疱症; 蚊刺過敏症; EBV; 慢性活動性EBV感染症; T; NKリンパ球増殖症; γδT細胞; NK細胞; EBウイルス; 潜伏感染; リンパ腫; 慢性活動性EBウイルス感染症; NK細胞増殖症; NK細胞リンパ腫; HDAC阻害; ウイルス発癌; CAEBV

We have established a disease spectrum of EB virus (EBV)-associated T/NK-cell lymphoproliferative disorders (LPD), including hydroa vacciniforme (HV), hypersensitivity to mosquito bites (HMB) and chronic active EBV infections, and analysed their pathogeneses by cellular and molecular basis. In these disorders, we found that 1) in addition to the cutaneous and hematological symptoms, oculomucosal and gastrointestinal lesions were major complications, 2) EBV-infected cell types related to the development of these disorders were of γδT cells in HV, and of NK cells in HMB, 3) reactivation of EBV from the latent infection, or alterations of latency infection patterns were important to induce the clinical symptoms, 4) host cytotoxic T lymphocyte (CTL) ?mediated immune responses were induced against lytic-cycle infection-associated EBV antigens, 5) clinical significance of monitoring EBV DNA load, and 6) a possible therapeutic use of HDAC inhibitors.

我们建立了 EB 病毒 (EBV) 相关 T/NK 细胞淋巴增殖性疾病 (LPD) 的疾病谱，包括痘痘水痘 (HV)、蚊虫叮咬过敏 (HMB) 和慢性活动性 EBV 感染，并通过以下方法分析了其发病机制：在这些疾病中，我们发现：1）除了皮肤和血液学症状外，眼粘膜和胃肠道病变也是主要的。并发症，2) 与这些疾病的发展相关的 EBV 感染细胞类型是 HV 中的 γδT 细胞和 HMB 中的 NK 细胞，3) EBV 从潜伏感染中重新激活，或潜伏感染模式的改变对于诱导临床症状，4) 诱导宿主细胞毒性 T 淋巴细胞 (CTL) 介导的针对裂解周期感染相关 EBV 抗原的免疫反应，5) 监测 EBV DNA 载量的临床意义，以及6) HDAC抑制剂的可能的治疗用途。

项目成果

NK-cell Tumor Study Group. Prognostic factors for mature natural killer (NK) cell neoplasms : aggressive NK cell leukemia and extranodal NK cell lymphoma, nasal type.

NK 细胞肿瘤研究组。

• 发表时间: 2010
• 期刊: Ann Oncol 21
• 作者: Suzuki R;Suzumiya J;Yamaguchi M;Nakamura S;Kameoka J;Kojima H;Abe M;Kinoshita T;Yoshino T;Iwatsuki K;Kagami Y;Tsuzuki T;Kurokawa M;Ito K;Kawa K;Oshima K.
• 通讯作者: Oshima K.

Skin Cancer-A World-wide Perspective. Springer, Heidelberg(Dummer R, Pittelkow MR, Iwatsuki K, Green A, Elwan NM (ed))

皮肤癌——全球视角。

• 发表时间: 2011
• 作者: Dainichi T;Ueda S;Furue M;Hashimoto T.;水口雅;Iwatsuki K.
• 通讯作者: Iwatsuki K.

Re-evaluation of CD34-negaitve dermatofibrosarcoma protuberans with a highly sensitive, tyramide-based immunohistochemical analysis.

使用高度灵敏、基于酪酰胺的免疫组织化学分析重新评估 CD34 阴性隆起性皮肤纤维肉瘤。

• 发表时间: 2008
• 期刊: European Journal of Dermatology 18
• 作者: Nakanishi G;Suzuki N;Lin SN;Asagoe K;Iwatsuki K
• 通讯作者: Iwatsuki K

Clinical Endpoints and Response Criteria in Mycosis Fungoides and Sezary Syndrome : a Consensus Statement of the International Society for Cutaneous Lymphomas (ISCL), the United States Cutaneous Lymphoma Consortium (USCLC) and the Cutaneous Lymphoma Task

蕈样肉芽肿和塞扎里综合征的临床终点和缓解标准：国际皮肤淋巴瘤协会 (ISCL)、美国皮肤淋巴瘤联盟 (USCLC) 和皮肤淋巴瘤任务的共识声明

• 发表时间: 2011
• 期刊: Journal of Clinical Oncology
• 影响因子: 45.3
• 作者: Olsen E;et al
• 通讯作者: et al

Human leukocyte antuigen genotypes and antibody profiles associated with familial pemphigus in Japanese

日本人白细胞抗原基因型和与家族性天疱疮相关的抗体谱

• 发表时间: 2010
• 期刊: Journal of Dermatology
• 影响因子: 3.1
• 作者: Yamamoto T