Pathological roles of a citrullinating enzyme PADI4 in rheumatoid arthritis

瓜氨酸酶 PADI4 在类风湿性关节炎中的病理作用

• 批准号: 20390280
• 负责人: YAMAMOTO Kazuhiko
• 金额: $ 11.98万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390280/
• 关键词: 免疫学; ゲノム; 内科; 遺伝子

We have previously identified rheumatoid arthritis susceptibility polymorphisms in PADI4. This enzyme converts arginine residues to citrullines and anti-citrullinated peptide antibodies are the most specific autoantibodies in the disease. In order to understand the pathological mechanisms, we have generated and analyzed arthritis in PADI4 knock out mice.

我们之前已经鉴定出 PADI4 中的类风湿性关节炎易感性多态性。这种酶将精氨酸残基转化为瓜氨酸，而抗瓜氨酸肽抗体是该疾病中最具特异性的自身抗体。为了了解其病理机制，我们在 PADI4 敲除小鼠中生成并分析了关节炎。

项目成果

Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.

• DOI: 10.1371/journal.pgen.1002067
• 发表时间: 2011-06
• 期刊: PLoS genetics
• 影响因子: 4.5
• 作者: Okada Y;Hirota T;Kamatani Y;Takahashi A;Ohmiya H;Kumasaka N;Higasa K;Yamaguchi-Kabata Y;Hosono N;Nalls MA;Chen MH;van Rooij FJ;Smith AV;Tanaka T;Couper DJ;Zakai NA;Ferrucci L;Longo DL;Hernandez DG;Witteman JC;Harris TB;O'Donnell CJ;Ganesh SK;Matsuda K;Tsunoda T;Tanaka T;Kubo M;Nakamura Y;Tamari M;Yamamoto K;Kamatani N
• 通讯作者: Kamatani N

Splenic phagocytes promote responses to nucleosomes in (NZB x NZW) F1 mice.

• DOI: 10.4049/jimmunol.181.8.5264
• 发表时间: 2008-10-15
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Okamoto A;Fujio K;van Rooijen N;Tsuno NH;Takahashi K;Tsurui H;Hirose S;Elkon KB;Yamamoto K
• 通讯作者: Yamamoto K

PAD14 polymorphism predisposes male smokers to rheumatoid arthrilis.

PAD14 多态性使男性吸烟者易患类风湿性关节炎。

• 发表时间: 2011
• 期刊: Ann Rheum Dis
• 影响因子: 27.4
• 作者: Kochi Y;Thabet MM;Suzuki A;Okada Y;Daha NA;Toes REM;Huizinga TWJ;Myouzen K;Kubo M;Yamada R;Nakamura Y;Yamamoto K
• 通讯作者: Yamamoto K