Study on toxic mechanism of chemical substances eluted from containers and packages and risk assessment

容器包装化学物质溶出毒性机理研究及风险评估

• 批准号: 20390171
• 负责人: NASU Tamie
• 金额: $ 11.56万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390171/
• 关键词: スチレントリマー; オクタクロロスチレン; アリールハイドロカーボン受容体; 甲状腺ホルモン; グルクロン酸抱合酵素; CYP1A1; ダイオキシン; 妊娠マウス; メカニズム; AAhR; UGT; 3-メチルコラントレン; Hepa-1c1c7; luciferase活性; MCF-7; AhR; 次世代影響; 環境ホルモン作用; 薬物代謝酵素; グルクロン酸転移酵素(UGT); T4; T3; 容器・包装品; リスク評価

Wild-type and aromatic hydrocarbon receptor(AhR)-null male mice were orally given 0, 32 and 64. mol/kg styrene trimer or octachloroatyrene for 4 days. Unexpectedly, styrene trimer down-regulated AhR mRNA expression, and accordingly down-regulated CYP1A1 and UGT1A1 and 1A6 mRNA expressions in the liver of wild-type mice. These finding were not observed in AhR-null mice. As a result, styrene trimer increased plasma total and free T4 levels in the wild-type mice.Octachlorostyrene treatment transactivated AhR and induced CYP1A1 and UGT1A1 in the wild-type mice. However, this chemical did not influence plasma T4 lebels.

野生型和芳香族烃受体（AHR）效果为0、32和64。摩尔/kg苯乙烯三聚体或八氯拉托烯4天。出乎意料的是，苯乙烯三聚体下调AHR mRNA的表达，因此在野生型小鼠的肝脏中下调的CYP1A1和UGT1A1和1A6 mRNA表达。这些发现在AHR无效的小鼠中未观察到。结果，野生型小鼠中的苯乙烯三聚体增加了血浆总和游离T4水平。但是，该化学物质不影响血浆T4 lebels。

项目成果

Research Recommendations for Selected IARC-Classified Agents

• DOI: 10.1289/ehp.0901828
• 发表时间: 2010-10-01
• 期刊: ENVIRONMENTAL HEALTH PERSPECTIVES
• 影响因子: 10.4
• 作者: Ward, Elizabeth M.;Schulte, Paul A.;Cogliano, Vincent J.
• 通讯作者: Cogliano, Vincent J.

Bisphenol A may cause testosterone reduction by adversely affecting both testis and pituitary systems similar to estradiol

• DOI: 10.1016/j.toxlet.2010.02.002
• 发表时间: 2010-04-15
• 期刊: TOXICOLOGY LETTERS
• 影响因子: 3.5
• 作者: Nakamura, Daichi;Yanagiba, Yukie;Nakajima, Tamie
• 通讯作者: Nakajima, Tamie