Natural historical study of genes in genomes in view of the notion that a gene is segmented

鉴于基因被分段的概念，对基因组中的基因进行自然历史研究

• 批准号: 10836022
• 负责人: TATENO Yoshio
• 金额: $ 2.18万
• 依托单位: National Institute of Genetics
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10836022/
• 关键词: Natural history; Molecular evolution; Structural evolution; HLA; Genome; Operon; Mitochondria; Periplasmic binding protein; MIC; ゲノム断片重複; LINE; エポキシダーゼ; プロテオーム; 色素遺伝子; ゲノム比較; ゲノム進化; SINE; periplasmicタンパク; 高次構造進化; 分子系統; ミトコンドリア進化

We have carried out research in the following topics in the past two years with the view that a gene is composed of sub-units each of which corresponds to a structural or a functional unit of a protein and thus is considered to be an evolutionary unit of a gene.1. Evolutionary dynamics of a HLA genome region,2. Evolution of operons by comparison of the whole bacterial genome,3. Estimation of evolutionary rate over the whole E, coli genomes,4. Phylogeny of vertebrates on the basis of the whole mitochondrial genomes,5. Structural evolution of periplasmic binding proteins,6. Evolution of acetylcholin receptor units,7. Discovery of a new gene in eukaryote by proteome analysis,8. Evolution of the pigment synthesis system in ascidian,9. Database design for genome datat,10. Database management system for genome sequences.These topics do not seem be related each other at first glance. However, one can categorize 1,2,3 and 4 into genome evolution, 5 and 6 into evolution of functional and structural units, 7 and 8 into evolution of a genome as an interrelated complex of genes and non-genes, and 9 and 10 into genome databases. I strongly believe that those research outcomes will contribute to the study of natural history of genomes.

我们近两年开展了以下课题的研究，认为基因是由亚单位组成的，每个亚单位对应于蛋白质的一个结构或功能单位，因此被认为是一个进化单位。基因.1. HLA基因组区域的进化动力学，2。通过比较整个细菌基因组来观察操纵子的进化，3．估计整个大肠杆菌基因组的进化速率，4。基于整个线粒体基因组的脊椎动物系统发育，5。周质结合蛋白的结构进化，6。乙酰胆碱受体单位的进化，7。通过蛋白质组分析发现真核生物中的新基因，8。海鞘色素合成系统的演化，9．基因组数据的数据库设计，10。基因组序列数据库管理系统。乍一看，这些主题似乎彼此并不相关。然而，我们可以将1、2、3和4归类为基因组进化，将5和6归类为功能和结构单元的进化，将7和8归类为作为基因和非基因相互关联的复合体的基因组进化，将9和10归类为基因组进化。进入基因组数据库。我坚信这些研究成果将有助于基因组自然史的研究。

项目成果

Itoh, T. ら: "Evolutionary Instability of Operon Structures Disclosed by Sequence Comparisons of Complete Microbial Genomes"Mol. Biol. Evol.. 16. 332-346 (1999)

Itoh, T. 等人：“通过完整微生物基因组的序列比较揭示操纵子结构的进化不稳定性”，《分子生物学》，16. 332-346 (1999)

Watanabe, M ら: "A phoshate-induced gene which promotes Penicillium mediated bioconversion of cis-propenylphosphnic acid to Fosfomycia"*plied and Environmental Microbiology. 65. 1036-1044 (1999)

Watanabe, M 等人：“促进青霉菌介导的顺式丙烯基次膦酸生物转化为磷霉菌的磷酸盐诱导基因”*plied 和环境微生物学 (Environmental Microbiology) 65. 1036-1044 (1999)。

Itoh, T. ら: "Evolutionary Instability of Operon Structures Disclosed by Sequence Comparisons of Complete Microbial Genomes"Mol. Biol. Evol.. 16. 332-346 (1999)

Itoh, T. 等人：“通过完整微生物基因组的序列比较揭示操纵子结构的进化不稳定性”，《分子生物学》，16. 332-346 (1999)

Hatta,Y.: "HLA genes and haplotypes in Ryukyuan suggest a recent gene flow to the Okinawa islands" Hyman Biology. (in press).

Hatta,Y.：“琉球的 HLA 基因和单倍型表明最近有基因流向冲绳群岛”海曼生物学。

Hatta, Y. ら: "HLA genes and haplotypes in Ryukyuan suggest a recent gene flow to the Okinawa islands"Human Biology. 71・3. 353-365 (1999)

Hatta, Y. 等人：“琉球的 HLA 基因和单倍型表明最近的基因流向冲绳群岛”人类生物学 71・3 (1999)。