Exploratory studies on mandibular prognathism susceptibility genes and functional analysis based on genome wide analysis

基于全基因组分析的下颌前突易感基因探索性研究及功能分析

• 批准号: 19592366
• 负责人: YAMAGUCHI Tetsutaro
• 金额: $ 2.91万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19592366/
• 关键词: 下顎前突症; ゲノム; 遺伝子; 頭蓋顎顔面形態

We studied the relationship between six polymorphism genotypes and craniofacial linear measurements obtained from lateral cephalograms of 326 East Asian subjects. There was a significant association between P561T and C422F polymorphisms and mandibular ramus height. These polymorphisms were found almost exclusively in the Asian population, with extremely small frequencies in other populations. GHR polymorphisms are associated with mandibular ramus height in the East Asian population, but this association is likely to be different in other ethnic groups, and may partly explain the differing craniofacial morphology seen among different ethnicities.

我们研究了从326位东亚受试者的侧面头部图获得的六种多态性基因型与颅面线性测量之间的关系。 P561T和C422F多态性与下颌Ramus高度之间存在显着关联。这些多态性几乎完全在亚洲人口中，在其他人群中的频率极小。 GHR多态性与东亚人口中的下颌公羊高度有关，但是在其他种族中，这种联系可能会有所不同，并且可能部分解释了不同种族中不同颅面形态的不同。

项目成果

A Common Variation in EDAR Is a Genetic Determinant of Shovel-Shaped Incisors

• DOI: 10.1016/j.ajhg.2009.09.006
• 发表时间: 2009-10-09
• 期刊: AMERICAN JOURNAL OF HUMAN GENETICS
• 影响因子: 9.8
• 作者: Kimura, Ryosuke;Yamaguchi, Tetsutaro;Oota, Hiroki
• 通讯作者: Oota, Hiroki

歯形態の遺伝学:シャベル型切歯とEDAR

牙齿形态遗传学：铲形门牙和 EDAR

• 发表时间: 2009
• 作者: 木村亮介;山口徹太郎;槙宏太郎;武田摩耶子;近藤修;埴原恒彦;大沢資樹;石田肇;河村正二;太田博樹
• 通讯作者: 太田博樹