Development of hybrid implant biomaterials by excimer laser irradiation and study on laser-tissue interaction mechanism

准分子激光辐照混合植入生物材料的开发及激光与组织相互作用机制的研究

• 批准号: 10650722
• 负责人: NAKAYAMA Takeyoshi
• 金额: $ 2.18万
• 依托单位: Kinki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10650722/
• 关键词: Laser ablation; Laser irradiation effect; Ceramics; Surface modification; Biocompatible materials; Alumina; Hydroxyapatite; Titanium; 疑似生体液

The aims of this project are (1) Development of a biocompatible material which is implant in living human body by using excimer laser irradiation method and (2) Elucidation of laser light-tissue interaction mechanism.The results obtained in this project are as follows ;A. Development of biocompatible material(1) Formation of hydroxyapatite (HAp) layer on AlィイD22ィエD2OィイD23ィエD2 substrate by excimer laser irradiation method was achieved.(2) Formation of a new bone on the surface of the above-mentioned sample was observed when the sample was immersed in stimulated body fluid (SBF) for 2 weeks.(3) A new laser irradiation method was developed for HAp coating on Ti.B. Laser light-tissue interaction mechanism.(1) The difference between KrF and ArF excimer laser irradiation effect for soft tissue was explained through the spectroscopic study.(2) Mechanism of laser ablation for hard tissue was elucidated by time-resolved photography.

该项目的目标是（1）开发一种利用准分子激光照射方法植入活体人体的生物相容性材料；（2）阐明激光光与组织的相互作用机制。该项目获得的结果如下： A.生物相容性材料的开发(1)采用准分子激光照射法在AliD22D2OD23D2基板上形成羟基磷灰石(HAp)层(2)将样品浸泡在刺激体液(SBF)中2周后，观察到在上述样品表面形成了新骨。(3)开发了一种新的HAp涂层激光照射方法(1)通过光谱研究解释了KrF和ArF准分子激光照射软组织效果的差异。(2)机理通过时间分辨摄影阐明了激光烧蚀硬组织。

项目成果

H. Nakano and T.Nakayama: "Mechanism associated with ArF and KrF excimer laser ablation of human tooth enamel"Rev. Laser Eng.. 26. 37 (1998)

H. Nakano 和 T.Nakayama：“与 ArF 和 KrF 准分子激光烧蚀人类牙釉质相关的机制”Rev。

M. Kuwata, T. Matsutani and T. Nakayama: "Hydroxyapatite coating methods for ceramics by using laser light (in Japanese)"Report on the 268ィイD1thィエD1 Topical Meeting of the Laser Society of Japan. RTM-99-27. 7 (1999)

M. Kuwata、T. Matsutani 和 T. Nakayama：“使用激光的陶瓷羟基磷灰石涂层方法（日语）”日本激光学会 RTM-99-27.7 268IiD1thieD1 专题会议的报告（1999 年）。

松谷、熊崎、中山: "エキシマレーザー照射による生体親和性材料の開発"光・量子デバイス研究会資料. OQD-98-47. 13-17 (1998)

Matsutani、Kumazaki、Nakayama：“通过准分子激光照射开发生物相容性材料”OQD-98-47 (1998)。

T. MATSUTANI, K. KUMAZAKI, T. NAKAYAMA: "Development of a hard tissue substitution material by UV laser irradiation method"Proceeding of The First Asian Pacific Laser Symposium. Wc-4 (1998)

T. MATSUTANI、K. KUMAZAKI、T. NAKAYAMA：“通过紫外激光照射方法开发硬组织替代材料”第一届亚太激光研讨会论文集。

T. Matsutani, K. Kumazaki and T. Nakayama: "Development of a hard tissue substitution materials by UV laser irradiation method"Proc. 1st Asian Pacific Laser Symposium Wc-4. (1998)

T. Matsutani、K. Kumazaki 和 T. Nakayama：“通过紫外激光照射方法开发硬组织替代材料”Proc。