An investigation of Tc-99m MIBI washout rate and kinetics in myocardium.

Tc-99m MIBI 洗脱率和心肌动力学的研究。

• 批准号: 19790850
• 负责人: OKIZAKI Atsutaka
• 金额: $ 1.43万
• 依托单位: Asahikawa Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19790850/
• 关键词: コンパートメントモデル解析; Tc-99m MIBI; 心筋血流; 洗い出し率; 薬物動態; Tc-99mMIBI; dynamic SPECT; コンパートメントモデル解析; Tc-99m MIBI; 心筋血流; 洗い出し率; 薬物動態; Tc-99mMIBI; dynamic SPECT

We performed a mathematical compartment model analysis with Tc-99m MIBI. A 2-compartment model was better than other model in our study. There were significant correlations between the rate constants and heart to mediastinum ratio. Therefore, the pharmacokinetics of Tc-99m MIBI might show the condition of myocardium. Moreover, the influx rate constant in patients with ischemic heart disease was reduced than it in normal control. This method might be useful to evaluate the condition of myocardial abnormality.

我们用TC-99M MIBI进行了数学隔室模型分析。在我们的研究中，一个2室模型比其他模型更好。速率常数与心脏与纵隔比之间存在显着相关性。因此，TC-99M MIBI的药代动力学可能显示出心肌的状况。此外，缺血性心脏病患者的涌入率常数比正常对照中的涌入率降低。此方法可能有助于评估心肌异常的状况。