The impact of hyperinsulinemia and tuberin in the development of hepatocellular carcinoma

高胰岛素血症和马铃薯素在肝细胞癌发生发展中的影响

• 批准号: 19790643
• 负责人: KAWAGUCHI Takumi
• 金额: $ 2.41万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19790643/
• 关键词: 糖尿病学; 肝細胞癌; インスリン抵抗性; tuberin; mTOR; 細胞増殖; インスリン情報伝達経路; HOMA-IR; 2型糖尿病; インスリン; mammalian target of rapamycin; insulin receptor substrate 1; Akt; 結節性硬化症

Hyperinsulinemia is frequently seen in patients with hepatocellularcarcinoma (HCC). Since insulin is a growth-promoting hormone, hyperinsulinemia may beinvolved in the development of HCC. In this study, we reveled that insulin may associate with the development of HCC though activation of intracellular molecules related to cell proliferation.

高胰岛素血症常见于肝细胞癌（HCC）患者。由于胰岛素是一种促生长激素，高胰岛素血症可能与 HCC 的发展有关。在这项研究中，我们发现胰岛素可能通过激活与细胞增殖相关的细胞内分子与 HCC 的发展相关。

项目成果

USE OF EXOGENOUS INSULIN OR SULFONYLUREA ASSOCIATED WITH AN INCREASED INCIDENCE OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH HEPATITIS C VIRUS INFECTION

使用外源性胰岛素或磺酰脲类药物会增加丙型肝炎病毒感染患者的肝细胞癌发病率

• 发表时间: 2009
• 作者: 曽根正勝;中尾一和;Kawaguchi T et al.
• 通讯作者: Kawaguchi T et al.

Pigment Epithelium-Derived Factor Inhibits Lysosomal Degradation of Bcl-xL and Apoptosis in HepG2 cells

• DOI: 10.2353/ajpath.2010.090242
• 发表时间: 2010-01-01
• 期刊: AMERICAN JOURNAL OF PATHOLOGY
• 影响因子: 6
• 作者: Kawaguchi, Takumi;Yamagishi, Sho-ichi;Sata, Michio
• 通讯作者: Sata, Michio

Body cell mass is a useful parameter for assessing malnutrition and severity of disease in non-ascitic cirrhotic patients with hepatocellular car cinoma or esophageal varices

体细胞量是评估患有肝细胞癌或食管静脉曲张的非腹水性肝硬化患者营养不良和疾病严重程度的有用参数

• 发表时间: 2008
• 期刊: Int J Mol Med 22
• 作者: Kawaguchi T;et.al.
• 通讯作者: et.al.

Branched-chain amino acid-enriched supplementation improves insulin resistance in patients with chronic liver disease.

• DOI: 10.3892/ijmm.22.1.105
• 发表时间: 2008-07
• 期刊: International journal of molecular medicine
• 影响因子: 5.4
• 作者: T. Kawaguchi;Y. Nagao;H. Matsuoka;T. Ide;M. Sata

Pigment Epithelium-Derived Factor Suppresses Apoptosis through Lysosomal Degradation of Bcl-xL in HepG2 cells.

色素上皮衍生因子通过溶酶体降解 HepG2 细胞中的 Bcl-xL 抑制细胞凋亡。

• 发表时间: 2009
• 作者: Kawaguchi T;et al.
• 通讯作者: et al.