Carcinogenic risk assessment of nano-sized particles

纳米粒子的致癌风险评估

• 批准号: 19590393
• 负责人: IMAIDA Katsumi
• 金额: $ 2.91万
• 依托单位: Kagawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590393/
• 关键词: ナノサイズ粒子; ラット肝中期発癌試験; 気管内投与; 強制胃内投与; 経静脈投与; GST-P positive foci; 酸化銅; 二酸化チタン; ナノサイズ微粒子; 発がんリスク; 腫瘍; 肝発がん; 中期発がん性試験法; ラット; 経気管内投与

Carcinogenesis of nanoparticles remains uncertain despite nano-sized materials are widely used. In this study, liver carcinogenesis of nano- and micro-sized particles (Copper oxide;CuO, Titanium dioxide ; TiO_2) was examined after exposure of three different routes. Consequently, these results indicate that nanoparticles have promoting potential on the liver carcinogenesis.

尽管纳米材料被广泛使用，但纳米颗粒的致癌作用仍然不确定。在本研究中，在三种不同途径暴露后，检查了纳米和微米尺寸颗粒（氧化铜；CuO，二氧化钛；TiO_2）的肝癌致癌作用。因此，这些结果表明纳米颗粒具有促进肝癌发生的潜力。

项目成果

Lack of Modifying Effects of Intratracheal Instillation of Quartz or Dextran Sulfate Sodium (DSS) in Drinking Water on Lung Tumor Development Initiated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Female A/J Mice.

• DOI: 10.1293/tox.22.179
• 发表时间: 2009-09
• 期刊: Journal of toxicologic pathology
• 影响因子: 1.2
• 作者: Yokohira M;Hashimoto N;Yamakawa K;Suzuki S;Saoo K;Kuno T;Imaida K
• 通讯作者: Imaida K

Lack of modifying potential of 8-methoxypsoralen in the promotion or progression stages of lung carcinogenesis in A/J emale ice.

8-甲氧基补骨脂素在 A/J 雌性冰中肺癌发生的促进或进展阶段缺乏修饰潜力。

• 发表时间: 2008
• 期刊: Oncol.Rep. 20(4)
• 作者: Kuno T;Yokohira M;Matsuda Y;Suzuki S;Hashimoto N;Yamakawa K;Saoo K;Imaida K.
• 通讯作者: Imaida K.

Detection of Carcinogenic and Modifying Potentials by Test Compounds Using a Mouse Lung Carcinogenesis Bioassay

使用小鼠肺癌发生生物测定法检测测试化合物的致癌和修饰潜力

• 发表时间: 2007
• 期刊: J.Toxicol.Pathol. 20
• 作者: Imaida K;Yokohira Y;Kuno T
• 通讯作者: Kuno T

Different threshold levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MelQx) initiation of lung and colon carcinogenesis and the effects of an additional initiation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice.

2-氨基-3,8-二甲基咪唑并[4,5-f]喹喔啉 (MelQx) 引发肺癌和结肠癌的不同阈值水平以及 4-(甲基亚硝基氨基)-1-(3-吡啶) 额外引发的影响

• 发表时间: 2010
• 期刊: Molecular Medicine Reports 3
• 作者: Suzuki S;Yokohira M;Hashimoto N;Saoo K;Matsuda Y;Yamakawa K;Nakano Y;Kuno T;Imaida K.
• 通讯作者: Imaida K.

Risk analysis of environmental chemicals on lung carcinogenesis.

环境化学物质对肺癌发生的风险分析。

• 发表时间: 2010
• 期刊: Asian Pacific J Cancer Prev 11
• 作者: Imaida K;Yokohira M;Hashimoto N;Kuno T.
• 通讯作者: Kuno T.