Elucidation of erythrocyte recognition and invasion by Babesia parasites

阐明巴贝虫寄生虫对红细胞的识别和侵袭

• 批准号: 19580334
• 负责人: YOKOYAMA Naoaki
• 金额: $ 2.91万
• 依托单位: Obihiro University of Agriculture and Veterinary Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19580334/
• 关键词: 寄生体生物; 感染症; 獣医学; 糖鎖; 動物; 衛生; バベシア原虫; 赤血球; 侵入

Sialic acids and Heparan sulfate located on erythrocytes were demonstrated to play important roles as infectious receptors in the erythrocyte invasion by Babesia parasites. In contrast, several protozoan proteins were also identified as new protozoan ligand candidates. Effects of glycoconjugates or specific antibodies on interfering the specific interactions between the protozoan ligands and erythrocyte receptors would provide us novel knowledge or materials for the development of chemotherapeutic and preventive mesures against babesionsis.

红细胞上的唾液酸和硫酸乙酰肝素被证明作为感染受体在巴贝虫寄生虫入侵红细胞中发挥重要作用。相比之下，几种原生动物蛋白也被鉴定为新的原生动物配体候选者。糖缀合物或特异性抗体对干扰原生动物配体和红细胞受体之间的特异性相互作用的作用将为我们开发针对巴贝西虫病的化疗和预防措施提供新的知识或材料。

项目成果

Cloning and characterization of peroxiredoxin in Babesia bovis

• DOI: 10.1007/s00436-009-1587-6
• 发表时间: 2009-10-01
• 期刊: PARASITOLOGY RESEARCH
• 影响因子: 2
• 作者: Tanaka, Miho;Sakurai, Tatsuya;Kawazu, Shin-ichiro
• 通讯作者: Kawazu, Shin-ichiro

Effect of oligomannose-coated liposome-based vaccine on rodent babesiosis

低聚甘露糖包被的脂质体疫苗对啮齿动物巴贝斯虫病的作用

• 发表时间: 2009
• 期刊: J. Protozool. Res. 19
• 作者: Ishigame;T.;Takabatake;N.;Iseki;H.;Ota;N.;Koyama;A.;Igarashi;I.;Nishikawa;Y.;Ikehara;Y.;Kojima;N.;Yokoyama;N.
• 通讯作者: N.

タイにおけるウシバベシア症の疫学調査

泰国牛巴贝斯虫病流行病学调查

• 发表时间: 2008
• 作者: 周麗佳;井関博;Tawin Inpankaew;横山直明;玄学南;Sathaporn Jittapalapong;五十嵐郁男
• 通讯作者: 五十嵐郁男

Involvement of host sialic acids in erythrocyte invasion of Babesia parasites

宿主唾液酸参与巴贝虫寄生虫的红细胞侵袭

• 发表时间: 2007
• 作者: 佐藤晃一;鳥橋茂子;堀正敏;那須哲之;博;尾.;Naoaki Yokoyama
• 通讯作者: Naoaki Yokoyama

Development of two immunochromatographic tests for the serodiagnosis of bovine babesiosis

• DOI: 10.1016/j.vetpar.2007.05.016
• 发表时间: 2007-09-01
• 期刊: VETERINARY PARASITOLOGY
• 影响因子: 2.6
• 作者: Kim, Chulmin;Alhassan, Andy;Igarashi, Ikuo
• 通讯作者: Igarashi, Ikuo