Analysis of T cell epitope in Asian type multiple sclerosis

亚洲型多发性硬化症T细胞表位分析

• 批准号: 08670712
• 负责人: KIRA Jun-ichi
• 金额: $ 1.34万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670712/
• 关键词: multiple sclerosis; disease susceptibility; HLA; Japanese; Asian; Helper T cell; HLA-DPB1^<**>0501; IFNgamma; HLA DPB1^*0501; multiple sclerosis; magnetic resonance imaging; Asian; Western; atopy; IgE; mite

We studied the polymorphism of HLA-A-DPBl gene in 90 Japanese patients with multiple sclerosis (MS) including 44 patients with Asian type MS showing recurrent opticomyelitis and 46 patients with Westem type MS with disseminated central nervous system involvement. We earlier found a significant association between an HLA-DRB1^<**> 1501-DRB5^<**>0101 haplotype and susceptibility to Western type but not Asian type MS.In the present work, we found that the frequency of DPB1^<**>0501 allele was significantly increased in the patients with Asian type MS (88.6% vs. 63.0%, p^<COIT><0.05), but not Western type MS,as compared with findings in healthy control subjects. In addition, Asian type MS showed a higher age of onset, a higher Expanded Disability Status Scale score, a greater visual impairment, a higher frequency of hyperprolactinemia and higher cell counts and protein contents in the cerebrospinal fluid than did Westem type MS.Our data provide further evidence that Asian and Western type MS are distinct regarding the immunogenetic backgound, and suggested that Asian type MS is a HLA-DPBl^<**>0501-restricted autoimmune disease.

我们研究了 90 名日本多发性硬化症 (MS) 患者的 HLA-A-DPBl 基因多态性，其中包括 44 名表现出复发性视脊髓炎的亚洲型 MS 患者和 46 名伴有播散性中枢神经系统受累的西方型 MS 患者。我们之前发现 HLA-DRB1^<**> 1501-DRB5^<**>0101 单倍型与西方型 MS 易感性之间存在显着关联，但与亚洲型 MS 无关。在本研究中，我们发现 DPB1^ 的频率<**>0501 等位基因在亚洲型 MS 患者中显着增加（88.6% vs. 63.0%，p^<COIT><0.05），但没有增加西方型多发性硬化症，与健康对照受试者的发现相比。此外，与西方型多发性硬化症相比，亚洲型多发性硬化症的发病年龄更高，扩展残疾状态量表评分更高，视力障碍更严重，高催乳素血症发生频率更高，脑脊液中细胞计数和蛋白质含量更高。我们的数据提供了进一步的证据表明亚洲型和西方型多发性硬化症在免疫遗传学背景方面是不同的，并表明亚洲型多发性硬化症是一种HLA-DPBl^<**>0501限制性自身免疫性疾病。