Development of rapid and simultaneous diagnosis and therapy for musculoskeletal sarcomas using acridine orange excited by high-power flash light
使用高功率闪光灯激发吖啶橙快速同步诊断和治疗肌肉骨骼肉瘤的进展
基本信息
- 批准号:19390390
- 负责人:
- 金额:$ 10.82万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2007
- 资助国家:日本
- 起止时间:2007 至 2009
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
To develop photodynamic diagnosis and photodynamic therapy using acridine orange excited by high-power flash light provided from xenon lamp in musculoskeletal sarcomas, we performed this study using mouse osteosarcoma model. Results showed that it was possible to brilliantly detect tumor localization through skin by PDD and to strongly inhibit tumor growth by PDT after intravenous AO injection followed by flash light illumination.
为了使用肌肉骨骼肉瘤中Xenon灯提供的高功率闪光灯激发的Acridine橙色激发光动力诊断和光动力疗法,我们使用小鼠骨肉瘤模型进行了这项研究。结果表明,有可能通过PDD出色地检测到通过皮肤通过皮肤定位,并在静脉注射静脉注射后强烈抑制PDT的肿瘤生长,然后抑制闪光灯照明。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alternating electromagnetic field
- DOI:10.1007/s10585-007-9068-8
- 发表时间:2007-01-01
- 期刊:
- 影响因子:4
- 作者:Matsumine, Akihiko;Kusuzaki, Katsuyuki;Uchida, Atsurnasa
- 通讯作者:Uchida, Atsurnasa
A new therapeutic modality involving acridine orange excitation by photon energy used during reduction surgery for rhabodomyosarcomas.
一种新的治疗方式,涉及横纹肌肉瘤减容手术期间使用的光子能量激发吖啶橙。
- DOI:
- 发表时间:2009
- 期刊:
- 影响因子:0
- 作者:Matsubara T;Kusuzaki K;Matsumine A;Murata H;Satonaka H;Shinntani K;Nakamura T;Hosoi H;Iehara T;Sugimoto T;Uchida A
- 通讯作者:Uchida A
Clinical outcomes of minimally invasive surgery using acridine orange for musculoskeletal sarcomas around the forearm, compared with conventional limb salvage surgery after wide resection.
与广泛切除后的传统保肢手术相比,使用吖啶橙微创手术治疗前臂周围肌肉骨骼肉瘤的临床结果。
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Matsubara T;Matsumine A.;et.al
- 通讯作者:et.al
Extracorporeal photodynamic image detection of mouse osteosarcoma in soft tissues utilizing fluorovisualization effect of acridine orange.
利用吖啶橙荧光可视化效应对小鼠软组织骨肉瘤进行体外光动力图像检测。
- DOI:
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:Satonaka H.;et al.
- 通讯作者:et al.
Extracorporeal Photodynamin Image Detection of Mouse Osteosarcoma in Soft Tissue Utilizing Fluorovisualizatiom Effect of Acridine Orange
利用吖啶橙荧光可视化作用进行体外光动力图像检测小鼠软组织骨肉瘤
- DOI:
- 发表时间:2007
- 期刊:
- 影响因子:0
- 作者:Satonaka H;Kusuzaki K;et. al.
- 通讯作者:et. al.
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KUSUZAKI Katsuyuki其他文献
KUSUZAKI Katsuyuki的其他文献
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{{ truncateString('KUSUZAKI Katsuyuki', 18)}}的其他基金
Challenging study of immunotherapy for osteosarcoma usingmicroparticles induced by photodynamic therapy
使用光动力疗法诱导的微粒进行骨肉瘤免疫治疗的挑战性研究
- 批准号:
23659730 - 财政年份:2011
- 资助金额:
$ 10.82万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Development of photodynamic and radiodynamic therapy with acridine orange for new limb salvage surgery in musculoskeletal sarcomas
吖啶橙光动力和放射动力疗法在肌肉骨骼肉瘤保肢手术中的应用进展
- 批准号:
14207058 - 财政年份:2002
- 资助金额:
$ 10.82万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Development of a new surgical strategy in tumor resection for malignant bone and soft tissue tumors with cytocidal effect of acridine orange excited by various dynamic energy-wave.
各种动态能量波激发吖啶橙的杀细胞作用,发展恶性骨和软组织肿瘤切除的新手术策略。
- 批准号:
12470312 - 财政年份:2000
- 资助金额:
$ 10.82万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Basic research on cell-biological feature of multidrug resistant osteosarcoma and overcoming of resistance
多重耐药骨肉瘤细胞生物学特征及克服耐药性的基础研究
- 批准号:
07457340 - 财政年份:1995
- 资助金额:
$ 10.82万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
DETECTION OF MULTI-DRUG RESISTANCY IN MALIGNANT BONE AND SOFT TISSUE TUMORS BY ADRIAMYCIN BINDING ASSAY
阿霉素结合试验检测恶性骨和软组织肿瘤的多药耐药性
- 批准号:
05671224 - 财政年份:1993
- 资助金额:
$ 10.82万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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