Regulatory Mechanism of Brain-Gut Interactions by Brain-Gut Peptides

脑肠肽对脑肠相互作用的调节机制

• 批准号: 19390189
• 负责人: FUKUDO Shin
• 金额: $ 9.15万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390189/
• 关键词: 脳腸相関; 過敏性腸症候群; corticotropin-releasing hormone (CRH); 内臓感覚; 消化管運動; 脳画像; CRH-R1受容体; α-helical CRH; corticotropin-releasing hormone(CRH); CRH; 消化管知覚; CRH-R1

It is important to clarify the precise mechanism of brain-gut interactions and pathogenesis of irritable bowel syndrome (IBS). We focused on the role of corticotropin-releasing hormone (CRH) in these phenomena. Administration of non-peptide CRH antagonist improved visceral hypersensitivity and flare-up of inflammation in the animal model of IBS after the experimental colitis. Administration of peptide CRH antagonist improved electrophysiological properties of the brain in patients with IBS. Further studies on brain-gut peptides in this issue are warranted.

重要的是要阐明脑肠相互作用的确切机制和肠易激综合征（IBS）的发病机理。我们专注于皮质激素释放激素（CRH）在这些现象中的作用。实验性结肠炎后，非肽CRH拮抗剂的施用改善了IBS动物模型的内脏性超敏反应和炎症的爆发。肽CRH拮抗剂的给药改善了IBS患者大脑的电生理特性。有必要在此问题中对脑肠肽的进一步研究。

项目成果

Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome

• DOI: 10.1111/j.1365-2982.2009.01427.x
• 发表时间: 2010-05-01
• 期刊: NEUROGASTROENTEROLOGY AND MOTILITY
• 影响因子: 3.5
• 作者: Tana, C.;Umesaki, Y.;Fukudo, S.
• 通讯作者: Fukudo, S.

Sex and gender in irritable bowel syndrome

• DOI: 10.1007/s00535-006-1859-1
• 发表时间: 2006-06-01
• 期刊: JOURNAL OF GASTROENTEROLOGY
• 影响因子: 6.3
• 作者: Fukudo, Shin

Changes in salivary physiological stress markers induced by muscle stretching in patients with irritable bowel syndrome.

• DOI: 10.1186/1751-0759-2-20
• 发表时间: 2008-11-04
• 期刊: BIOPSYCHOSOCIAL MEDICINE
• 影响因子: 2.1
• 作者: Hamaguchi, Toyohiro;Fukudo, Shin;Kanazawa, Motoyori;Tomiie, Tadaaki;Shimizu, Kunihiko;Oyama, Mineo;Sakurai, Kohji
• 通讯作者: Sakurai, Kohji

Normal and abnormal processing of negative emotion by visceral stimulation. Workshops : Brain-Gut Axis.

内脏刺激对负面情绪的正常和异常处理。

• 发表时间: 2009
• 作者: Fukudo;S.;Shin Fukudo;Shin Fukudo;Shin Fukudo;Shin Fukudo;Shin Fukudo;Shin Fukudo;Shin Fukudo
• 通讯作者: Shin Fukudo

Normal and abnormal processing of negative emotion by visceral stimulation. Workshops : Brain-Gut Axis

内脏刺激对负面情绪的正常和异常处理。

• 发表时间: 2009
• 作者: Fukudo;S.;Shin Fukudo;Shin Fukudo;Shin Fukudo;Shin Fukudo;Shin Fukudo;Shin Fukudo;Shin Fukudo;Fukudo S.
• 通讯作者: Fukudo S.