Comprehensive study on molecular basis of actions of CCN family proteins as novel signal conductors and its translational application

CCN家族蛋白作为新型信号传导体的分子基础及其转化应用的综合研究

• 批准号: 19109008
• 负责人: TAKIGAWA Masaharu
• 金额: $ 70.72万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (S)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19109008/
• 关键词: CCNファミリー; シグナルコンダクター; 結合分子; 遺伝子発現; CCN2/CTGF; 分子間相互作用; CCN3/Nov; 軟骨; 骨; ハルミン; シグナル伝達; FGF2; DC-STAMP; 軟骨細胞; 破骨細胞; トランスジェニックマウス; GAPDH; CTGF; CCN2; Nov; FGF受容体; アグリカン; 歯肉線維芽細胞; RANK; ニコチン; 再生; BMP-2; ノックアウトマウス; 細胞分化

We have established a novel concept that CCN family proteins should be considered a newly classified signaling molecules that comprehensively regulate extracellular signals, and thus should be entitled "Signal Conductors." Moreover, we have accumulated basic data for application of CCN proteins toward harmonized regenerative medicine and for therapeutics of diseases with their abnormal upregulation, leading to their medical applications.

我们建立了一个新的概念，CCN家族蛋白应该被认为是一种新分类的信号分子，全面调节细胞外信号，因此应该被命名为“信号导体”。此外，我们还积累了CCN蛋白在协调再生医学中的应用及其异常上调疾病治疗的基础数据，从而实现了其医学应用。

项目成果

Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes

• DOI: 10.1111/j.1742-4658.2007.05709.x
• 发表时间: 2007-04-01
• 期刊: FEBS JOURNAL
• 影响因子: 5.4
• 作者: Yanagita, Takeshi;Kubota, Satoshi;Takigawa, Masaharu
• 通讯作者: Takigawa, Masaharu

Promotion of attachment of human bone marrow stromal cells by CCN2

• DOI: 10.1016/j.bbrc.2007.03.052
• 发表时间: 2007-05-25
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Ono, Mitsuaki;Kubota, Satoshi;Kuboki, Takuo
• 通讯作者: Kuboki, Takuo

CCN2 in orofacial tissue development and remodeling

• DOI: 10.1016/j.jdsr.2012.02.002
• 发表时间: 2012-08
• 期刊: Japanese Dental Science Review
• 影响因子: 6.6
• 作者: S. Kubota

Cooperative Regulation of Chondrocyte Differentiation by CCN2 and CCN3 Shown by a Comprehensive Analysis of the CCN Family Proteins in Cartilage

• DOI: 10.1359/jbmr.080615
• 发表时间: 2008-11-01
• 期刊: JOURNAL OF BONE AND MINERAL RESEARCH
• 影响因子: 6.2
• 作者: Kawaki, Harumi;Kubota, Satoshi;Takigawa, Masaharu
• 通讯作者: Takigawa, Masaharu

CCN family 2/connective tissue growth factor modulates BMP signaling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes.

CCN 家族 2/结缔组织生长因子作为信号传导体调节 BMP 信号传导，其作用调节软骨细胞的增殖和分化。

• 发表时间: 2009
• 期刊: J. Biochem. 145(2)
• 作者: Maeda;A.;et al.
• 通讯作者: et al.