An anti-c-Fms Antibody Inhibits Orthodontic Tooth Movement

抗 c-Fms 抗体抑制正畸牙齿移动

• 批准号: 18592242
• 负责人: KITAURA Hideki
• 金额: $ 2.49万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18592242/
• 关键词: Osteoclast; TNF-α; Orthodontic

Orthodontic force induces osteoclastogenesis in vivo. It has recently been reported that administration of an antibody against the macrophage-colony-stimulating factor(M-CSF)receptor c-Fms blocks osteoclastogenesis and bone erosion induced by tumor necrosis factor-α(TNF-α)administration. This study aimed to examine the effect of an anti-c-Fms antibody on mechanical loading-induced osteoclastogenesis and osteolysis in an orthodontic tooth movement model in mice. Using TNF receptor 1 and 2-deficient mice, we showed that orthodontic tooth movement was mediated by TNF-α. We injected anti-c-Fms antibody daily into a local site, for 12 days, during mechanical loading. The anti-c-Fms antibody significantly inhibited orthodontic tooth movement, markedly reduced the number of osteoclasts in vivo and inhibited TNF-α-induced osteoclastogenesis in vitro. These findings suggest that M-CSF plays an important role in mechanical loading-induced osteoclastogenesis and bone resorption during orthodontic tooth movement mediated by TNF-α.

最近有报道称，使用抗巨噬细胞集落刺激因子（M-CSF）受体 c-Fms 的抗体可阻断肿瘤坏死因子-α（TNF-α）诱导的破骨细胞生成和骨侵蚀。 ）本研究的目的是在小鼠正畸牙齿移动模型中检查抗 c-Fms 抗体对机械负荷诱导的破骨细胞生成和骨溶解的影响。在 TNF 受体 1 和 2 缺陷的小鼠中，我们发现正畸牙齿移动是由 TNF-α 介导的。我们在机械加载期间每天将抗 c-Fms 抗体注射到局部部位，持续 12 天。显着的抗体抑制了正畸牙齿的移动，显着减少了体内破骨细胞的数量，并抑制了体外TNF-α诱导的破骨细胞生成，这些发现表明M-CSF在机械作用中发挥着重要作用。 TNF-α 介导的正畸牙齿移动过程中负载诱导的破骨细胞生成和骨吸收。

项目成果

「研究成果報告書概要(和文)」より

摘自《研究结果报告摘要（日文）》

• 发表时间: 2005
• 作者: Kawauchi;et. al.;Nishimura et al.;Dezawa et al.;Yoshizawa et al.;星野 幹雄;星野 幹雄
• 通讯作者: 星野 幹雄

An anti-c-Fms antibody inhibits orthodontic tooth movement

• DOI: 10.1177/154405910808700405
• 发表时间: 2008-04-01
• 期刊: JOURNAL OF DENTAL RESEARCH
• 影响因子: 7.6
• 作者: Kitaura, H.;Yoshimatsu, M.;Yoshida, N.
• 通讯作者: Yoshida, N.