Computer aided skeletal reconstruction with use of Bone Morphogenetic Protein -Experimental study of new method for skeletal reconstructive surgery-

使用骨形态发生蛋白的计算机辅助骨骼重建-骨骼重建手术新方法的实验研究-

• 批准号: 18591640
• 负责人: NAKAMURA Hiroaki
• 金额: $ 2.49万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591640/
• 关键词: Tissue engineering; Bioactive material; Bone Morphogenetic Protein; Computer-assisted surgery; Computer aided designq; Anatomical reconstruction of bone; 生体活性セラミック; コンピュータ援用設計; 手術用ナビゲーションシステム

Reconstruction of large bone defects at various site with various size and shape are often encountered in clinical practice as results from surgical resection of bone and for soft tissue tumors or from the high energy injury. However, current modalities to repair the large bone defects are not enough and clinical outcomes are usually not satisfactory, even if with use of autogenous bone grafting. And novel methods to repair such large bone defects with high efficacy and accuracy in short periods are urged. This study is aiming at development of such a new technology to promote bone repair with combined use of a bioactive protein (bone morphogenetic protein-2, BMP-2) produced by DNA recombination technology, synthetic biomaterial (HA, hydroxyapatite) a synthetic polymer (polylactic acid-polyethylene glycol block co-polymer, PLA-PEG) and a biodegradable β tricalcium phosphate (βTCP) powder. As a preclinical study, we generated a pelvic bone defect model in dog, where optional defect in t … More he iliac bone was generated and the real-sized and shaped bone defect was determined based on computer tomography scanning data by subtracting the three-dimensional image of the affected iliac bone from mirror-imaged contralateral normal ilium. The 3-dimensional CT data of the bone defect was utilized to fabricate HA implant correctively identical to the bone defect by a computer aided designing (CAD) system Tb combine the CAD fabricated HA implant with BMP, PLA-PEG polymer and βTCP powder, small dose of BMP-2 (-100 μg) was mixed into paste-natured PLA-PEG polymer/ βTCP powder. (〜100mg respectively) and coated the HA implant surface and placed into the bone defect by surgical procedures. After surgery, the bone forming reactions were followed weekly by routine and CT scanning radiographyof the pelvis. New bone covering the implant started to appear in 3 weeks after surgery and completely covered whole implant in 9 weeks, On gross appearance of the retreaved ilium at 9 weeks after surgery, the original bone defect was completely repaired with new bone formation and restored normal anatomy of the ilium. The results indicated potential repair of large bone defects with use of synthetic materials (recombinant BMP-2, PLA-PGE polymer βTCP and Hablock) without use of bone grafting in short periods of time. Less

在骨骼的临床实践中，骨骼肿瘤和软能量损伤的临床实践经常会遇到大骨缺陷部位的重建。敦促具有高疗效的令人满意的效率，并在短期内进行精确度。羟基磷灰石）合成聚合物（聚乳酸多甲基Glycol块共聚物，pla-peg）和可生物降解的β磷酸三钙（βTCP）粉末。根据计算机断层扫描的数据，通过计算机断层扫描数据确定了镜像骨的三维图像，从镜像的骨骼正常illium中，骨缺损的3维CT数据用于fabrique ha pobrique ha Implector与骨头相同缺陷？粉末（约100毫克的尊重者），通过外科手术覆盖了HA植入物表面，骨骼缺陷。手术后，将纤维形成新的骨形成，并恢复了iLium的正常解剖体

项目成果

手術ナビゲーションシステム、CAD、CAMの使用による解剖学的健常な骨修復-BMPによる骨再生の新たな手法-

使用手术导航系统、CAD 和 CAM 进行解剖学上健康的骨修复 - 使用 BMP 进行骨再生的新方法 -

• 发表时间: 2006
• 作者: 並川 崇

関節外科 -基礎と臨床

关节外科 - 基础和临床

• 发表时间: 2008
• 作者: 並川 崇;高岡 邦夫
• 通讯作者: 高岡 邦夫