SYNTHESIS OF BONE THEN FILMS BY LASER ABLATION AND THEIR APPLICATIONS TO IMPLANT MATERIALS

激光烧蚀合成骨膜及其在植入材料中的应用

基本信息

批准号：
07680960
负责人：
HONTSU Shigeki
金额：
$ 1.02万
依托单位：
KINKI UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

项目摘要

The ArF excimer laser deposition technique has been used to fabricate bioceramic hydroxyapatite (HAp) thin films. the target was the pressed pellet, that was the mixture of HAp (Ca/P=2.03) powder and P_2O_5 powder for the control the Ca/P ratio of HAp films. The bone and tooth were also used as target. The crystallized HAp films were fabricated using a after annealing method or in-situ growth method. In the case of former method, the films were deposited in vacuum in pure oxygen gas (pressure 0.4 mTorr) at substrate temperature 100ﾟC.The films were annealed for 1-10 hr at 300-550ﾟC under the oxygen+water vapor flow. The HAp films have been grown on various inorganic or organic substrates, such as Ti, Al_2O_3/Si (100) and SrTiO_3 (100) inorganic materials, and polymides (PI) and polytetrafluoroethylene (PTFE) organic materials. The mechanical properties of HAp films were examined using a dynamic ultra-micro hardness tester and an Instron testing machine. The dynamic hardness was obtained to be 390 for HAp film on Ti substrate. Also, the tensile bond strengths of HAp film on PI and PTFE were 9.8MPa and 0.4MPa, respectively. and that of HAp film on Ti was more than 54MPa. In the case of latter method, the HAp films were deposited in vacuum in pure oxygen+water vapors (pressure 100mTorr) at temperature 450-550ﾟC.The formation of c-axis oriented HAp films has been accomplished on sapphire (0001) substrate The biocompatibility of HAp films were also studied by in-vitro experiments. In this experiment, 3T3-E1 cells were used for osteoblastic cells attachment models. As a results, the cells were attached and proliferated on the Ti substrate. This result indicate that the HAp films with laser ablation were useful for the biocompatible coating material of implant.

ArF准分子激光沉积技术已用于制备生物陶瓷羟基磷灰石（HAp）薄膜，目标是压制颗粒，即HAp（Ca/P=2.03）粉末和用于控制Ca/P的P_2O_5粉末的混合物。 HAp 薄膜的比例也被用作靶材，采用后退火法或原位生长法制备。在前一种方法的情况下，薄膜在纯氧气体（压力0.4毫托）中在真空中沉积，衬底温度为100℃。薄膜在氧气+水蒸气流下在300-550℃下退火1-10小时。 HAp 薄膜生长在各种无机或有机基底上，如 Ti、Al_2O_3/Si (100) 和 SrTiO_3 (100)无机材料、聚酰亚胺(PI)和聚四氟乙烯(PTFE)有机材料采用动态超显微硬度计和Instron试验机检测HAp薄膜的力学性能，测得动态硬度为390。另外，HAp 薄膜在 PI 和 PTFE 上的拉伸粘合强度分别为 9.8MPa 和 0.4MPa。后一种方法是在纯氧+水蒸气（压力100mTorr）、温度450-550℃下真空沉积HAp薄膜，形成c轴取向的HAp薄膜。 HAp 薄膜的生物相容性也通过体外实验进行了研究。 3T3-E1细胞用于成骨细胞附着模型，结果表明，激光烧蚀的HAp薄膜可用于植入物的生物相容性涂层材料。