Study of adaptability to oral environmental changes from brain plasticity perspective

从大脑可塑性角度研究口腔环境变化的适应性

基本信息

批准号：
18390510
负责人：
WATANABE Makoto
金额：
$ 10.05万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390510/
关键词：
fMRI motor learning oral environment oral function 脳可塑性脳機能

项目摘要

Nine subjects (mean age 28.7) underwent fMRI during chewing gum on the left side of jaw, with and without a resin cap on the lingual region of the maxillary left canine. fMRI acquisition protocol used in the present study has been optimised in our pilot study. fMRI was performed before, immediately after and 30min after applying resin cap. Six out of nine subjects were asked to masticate a wax cube on the left side of jaw in each condition to determine masticatory efficiency. fMRI data were analyzed with SPM2 (Statistical Parametric Mapping 2) to determine differences of brain activity (p=0.001 uncorrected, extent threshold=20voxels).During left side gum chewing, bilateral cerebellar posterior lobe and the proximal part of right supramarginal gyrus were more activated immediately after applying resin cap than before applying it. The activation of cerebellum might show the activity of cerebellum during "motor learning". During left side gum chewing, right cerebellar posterior lobe were less activated 30min after applying resin cap than immediately after applying it. This result might show that the motor learning of left masticatory muscles and the adaptation to left gum chewing with regin cap were achievement.The brain regions showing negative correlation to masticatory efficiency were bilateral postcentral gyrus, left precentral gyrus, right cingulate gyrus, right superior temporal gyrus, right cerebellar posterior lobe and right cerebellar anterior lobe. These findings suggest that right cerebellar posterior and anterior lobe were activated to achieve motor learning of left masticatory muscles to remedy reduced masticatory efficiency immediately after applying resin cap, and were less activated with the improvement of masticatory efficiency and achievement of motor learning 30min after applying resin cap.

9 名受试者（平均年龄 28.7 岁）在咀嚼左侧下颌口香糖期间接受了功能磁共振成像（fMRI），其中上颌左尖牙的舌部区域有或没有树脂帽。本研究中使用的功能磁共振成像采集协议已在我们的试点研究中进行了优化。在施加树脂帽之前、之后立即和之后 30 分钟进行 fMRI。九名受试者中的六名被要求在每种情况下咀嚼下颌左侧的蜡块，以确定咀嚼效率。使用SPM2（统计参数映射2）分析fMRI数据以确定大脑活动的差异（p=0.001未校正，范围阈值=20体素）。在左侧咀嚼牙龈期间，双侧小脑后叶和右侧缘上回近端部分更多与应用树脂盖之前相比，应用树脂盖后立即激活。小脑的激活可能表明小脑在“运动学习”过程中的活动。在咀嚼左侧口香糖期间，应用树脂帽后 30 分钟，右小脑后叶的激活程度低于应用树脂帽后立即的活性。这一结果可能表明左侧咀嚼肌的运动学习和对左口牙龈咀嚼的适应是成功的。与咀嚼效率呈负相关的脑区是双侧中央后回、左侧中央前回、右侧扣带回、右侧颞上回脑回、右小脑后叶和右小脑前叶。这些结果表明，在应用树脂帽后，右侧小脑后叶和前叶被激活，以实现左侧咀嚼肌的运动学习，以弥补咀嚼效率的降低，而在应用树脂帽后30分钟，随着咀嚼效率的提高和运动学习的实现，右侧小脑后叶和前叶的激活程度较低帽。