Development of novel membrane type artificial lung having controlled surface morphology

具有可控表面形态的新型膜式人工肺的开发

• 批准号: 07558131
• 负责人: NAGASAKI Yukio
• 金额: $ 3.46万
• 依托单位: Science University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07558131/
• 关键词: Artificial lung; Antithrombogenicity; poly (2-hydroxyethyl methacrylate); block copolymer; Silicon-containing polymers; polymer brush; Gas permselective membrane; 含ケイ素ポリマー; ガス透過; 血液適合性; 多相系表面; ぬれ; 膨潤度

Organosilicon-containing polystirene/poly (2-hydroxyethyl methacrylate)block copolymers were prepared by an anionic living polymerization technique. The obtained block copolymer showed unique thermodynamic properties. Especially, the block copolymer which possess only 10 mol% of poly (Si-stirene) segment showed very low glass transition temperature (Tg=10ﾟC) though both segments exhibit the fairly high Tgs (150 and 70ﾟC). The high flexibility of the copolymer chain caused extremely high blood compatibility. The obtained block copolymers also shows high gas exchange ability not only dry but also wet conditions due to the introduction of two organosilicon groups in each monomer unit. By construction of this film using this block copolymer on PP microporous membrane, the high performance membrane which possess both blood compatibility and high gas permeability was obtained.

采用阴离子活性聚合技术制备了含有机硅的聚苯乙烯/聚(甲基丙烯酸2-羟乙酯)嵌段共聚物，所得嵌段共聚物显示出独特的热力学性能，其中聚(Si-苯乙烯)含量仅为10 mol%。尽管这两个部分都表现出相当高的 Tg（150 和由于在每个单体单元中引入了两个有机硅基团，因此所获得的嵌段共聚物不仅在干燥条件下而且在潮湿条件下都表现出高气体交换能力。将这种嵌段共聚物应用于PP微孔膜上，得到兼具血液相容性和高透气性的高性能膜。

项目成果

Y.Nagasaki, H.Ito, M.Kato, K.Kataoka, T.Tsuruta: "Stabiliation of living end in the anionic polymerization of 2- (trimethylsiloxy) (ethyl methacrylate. Role of surrounding monomer molecules" Polymer Bulletin. 35 (1/2). 137-142 (1995)

Y.Nagasaki、H.Ito、M.Kato、K.Kataoka、T.Tsuruta：“2-（三甲基甲硅烷氧基）（甲基丙烯酸乙酯）阴离子聚合中活性末端的稳定。周围单体分子的作用”聚合物通报。35（

C.Scholz, M.Iijima, Y.Nagasaki, K.Kataoka: "A novel reactive polymeric micelles polymerc micele with aldehyde groups on its surface" Macromolecules, Communication to the Edito.28 (21). 7295-7296 (1995)

C.Scholz、M.Iijima、Y.Nagasaki、K.Kataoka：“一种新型反应性聚合胶束，表面带有醛基的聚合物胶束”Macromolecules，Communication to the Edito.28 (21)。

長崎幸夫: "A creation of an intelligent surface-The design of a reactive surface with stimuli-sensitivity toward temperature and pH-" Plenum(in press),

Yukio Nagasaki：“智能表面的创造 - 对温度和 pH 值具有刺激敏感性的反应表面的设计 -” Plenum（正在印刷中），

S.Cammas, A.Harada, Y.Nagasaki, K.Kataoka: "Poly (ethylene oxide-co-beta-benzyl-L-aspartate) block copolymers : Influence of the poly (ethylene oxide) block on the conformationof the poly (beta-benzyl-L-aspartat) segment in organic solvents" Macromolecule

S.Cammas、A.Harada、Y.Nagasaki、K.Kataoka：“聚（环氧乙烷-共-β-苄基-L-天冬氨酸）嵌段共聚物：聚（环氧乙烷）嵌段对聚（环氧乙烷）构象的影响”

S.Cammas, Y.Nagasaki, K.Kataoka: "Heterobifunctional poly (ethylene oxide) (PEO) Synthesis of alpha-methoxy-omega-amino and alpha-hydroxyl-omega-amino PEOs with the same molecular weight" Bioconjugate Chemistry, Technical Note. 6 (2). 226-230 (1995)

S.Cammas、Y.Nagasaki、K.Kataoka：“异双功能聚环氧乙烷 (PEO) 具有相同分子量的 α-甲氧基-omega-氨基和 α-羟基-omega-氨基 PEO 的合成”生物共轭化学、技术