Radiation sensitization targeting molecules involved in radiation-induced DNA damage repair system

辐射致敏靶向参与辐射诱导DNA损伤修复系统的分子

• 批准号: 18591376
• 负责人: AKIMOTO Tetsuo
• 金额: $ 2.24万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591376/
• 关键词: radiosensitivity; molecular target; DNA damage repair; radiation therapy; DNA損傷修復; DNA二重鎖切断; アポトーシス

We reported the correlation between changes in H2AX foci and radiosensitivity in various cancer cells, and demonstrated that repair system of radiation-induced DNA damage is closely associated with radioresponse or radiosensitivity of cancer cells. In addition, we explored the mechanism of thermal radiosensitization. The results of our study demonstrated that heat in combination with radiation decreased the formation of radiation-induced γH2AX foci and Nbsl, and preheating resulted in the increase in SF and decrease in the focus formation of γH2AX. Considering from the fact that γH2AX is a sensor for DNA damage site, the results of this study suggested the possibility that heat in combination with radiation would modify the repair process of radiation-induced DNA damage through masking of DNA damage site or inhibition of access of molecules that were involved in DNA damage repair to DNA damage site.

我们报道了H2AX灶的变化与各种癌细胞的放射敏感性之间的相关性，并证明了辐射诱导的DNA损伤的修复系统与癌细胞的辐射响应或放射性敏感性密切相关。此外，我们探索了热放射敏化的机理。我们的研究结果表明，与辐射诱导的热量诱导的γH2AX灶和NBSL相结合，预热导致SF的增加并减少γH2AX的焦点形成。考虑到γH2AX是DNA损伤位点的传感器，这项研究的结果表明，与辐射结合使用的热量可能会改变辐射诱导的DNA损伤的修复过程，通过掩盖DNA损伤部位或抑制与DNA损害损害DNA损伤部位有关的分子的访问。

项目成果

Anatomy-based inverse optimization in high-dose-rate brachytherapy combined with hypofractionated external beam radiotherapy for localized prostate cancer : Comparison of incidence of acute genitourinary toxiity between anatomy-based inverse optimization

基于解剖学的逆优化在高剂量率近距离放射治疗联合大分割外照射放射治疗局限性前列腺癌中的应用：基于解剖学的逆优化之间急性泌尿生殖毒性发生率的比较

• 发表时间: 2006
• 期刊: Int J Radiat Oncol Biol Phys 64(5)
• 作者: Ebara T;Akimoto T;et. al.;内田 政史;秋元哲夫;秋元哲夫;内田政史;Akimoto T. et al.
• 通讯作者: Akimoto T. et al.

Late rectal bleeding and genitourinary morbidity after high dose rate brachytherapy combined with hypofractionated external beam radiotherapy for localized prostate cancer

高剂量率近距离放射治疗联合大分割外照射治疗局限性前列腺癌后的晚期直肠出血和泌尿生殖系统发病率

• 发表时间: 2007
• 期刊: Int J Radiat Oncoi Biol Phys 19
• 作者: Ebara T;Akimoto T;et. al.
• 通讯作者: et. al.

HDR brachytherapy combined with hypofractionated EBRT for intermediate-high risk prostate cancer.

HDR 近距离放射治疗联合大分割 EBRT 治疗中高危前列腺癌。

• 发表时间: 2007
• 作者: Akimoto T;et. al.
• 通讯作者: et. al.

多分割照射法の放射線生物学的な基礎

多次照射的放射生物学基础

• 发表时间: 2007
• 期刊: 頭頸部癌 33
• 作者: 内田政史;谷川 仁;才田義文;迫田 順;長田周治;早渕尚文;秋元 哲夫
• 通讯作者: 秋元 哲夫

IMRTの治療計画から治療開始までの手順ならびに問題点

从 IMRT 治疗计划到治疗开始的步骤和问题

• 发表时间: 2007
• 期刊: 頭頸部癌 33(3)
• 作者: 羽生;裕二;黒岡;将彦;那須;佐知子;秋元;哲夫;三橋;紀夫
• 通讯作者: 紀夫