Aerobic Oxidation Reactions Catalyzed by Flavin Molecules

黄素分子催化的有氧氧化反应

• 批准号: 18550092
• 负责人: IMADA Yasushi
• 金额: $ 2.64万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18550092/
• 关键词: organocatalysts; flavin catalysts; aerobic oxidations; environmentally friendry; hydrogenation; diimide; dendrimers; gold nanoparticles; フラビンン触媒; フラビン触媒; ヒドラジン; グリーンケミストリー

Organocatalytic aerobic oxidation is one of the most attractive methods because of availability and safety of molecular oxygen and organocatalysts. In this project, the author developed highly selective and environmentally friendly methods for oxidation of heteroatom compounds as well as hydrogenation of olefins based on the flavin-promoted activation of molecular oxygen.1. Hydrazine was oxidized readily by flavinium cation-ratalyzed aerobic oxidation to give diazene, which is a highly active hydrogen donor towards unsaturated bonds. Using the system, the author developed environmentally f iendly hydrogenation method for olefins without using metal catalysts and hydrogen gas.3. Dendrimers bearing diaminopyridine core bind flavin molecules through three-point hydrogen bonding interaction to form flavin-dendrimer complexes. The compexes exhibited high catalytic performance due to the hydrohobic environment around the catalyst.3. Dendrimers bearing diaminopyridine core bind flavin molecules through three-point hydrogen bonding interaction to fomi flavin-dendrimer complexes. The compexes exhibited high catalytic performance due to the hydrohobic environment around the catalyst.4. Gold nanoparticles can be functionalized by flavin molecules. The flavin-functionalized gold nanoparticles can be used as catalysts for aerobic oxidation of sulfides and aerobic hydrogenation of of efins.

由于分子氧和有机催化剂的可用性和安全性，有机催化有氧氧化是最有吸引力的方法之一。在这个项目中，作者开发了基于黄素氧化的黄素促进的激活，开发了高度选择性和环保的方法来氧化杂原子化合物以及烯烃的氢化。1。通过黄阳离子阳离子催化的有氧氧化可容易地氧化氢氮，这是深苯，这是一个高度活跃的氢供体朝向不饱和键。使用该系统，作者在不使用金属催化剂和氢气的情况下为烯烃开发了环境化的氢化方法3。轴承二氨基吡啶核的树状聚合物通过三点氢键相互作用结合黄素分子，形成黄素树枝状聚合物复合物。由于催化剂周围的羟基环境，该组件表现出很高的催化性能。3。带有二氨基吡啶核的树状聚合物通过三点氢键相互作用与Fomi黄素树突复合物结合黄素分子。由于催化剂周围的羟基环境，该组件表现出高催化性能。4。黄金纳米颗粒可以通过黄素分子功能化。黄素功能化的金纳米颗粒可用作硫化物的有氧氧化和依辛的有氧氢化的催化剂。

项目成果

Flavins as organocatalysts for environmentally benign molecular transformations

• DOI: 10.1002/tcr.20135
• 发表时间: 2007-01-01
• 期刊: CHEMICAL RECORD
• 影响因子: 6.6
• 作者: Imada, Yasushi;Naota, Takeshi
• 通讯作者: Naota, Takeshi

Synthesis of macrocyclic dinitrones by ring expansion dimerization of cyclic nitrones

环硝酮扩环二聚合成大环二硝酮

• 发表时间: 2006
• 作者: Chiaki;Okita
• 通讯作者: Okita

Organocatalytic Aerobic Hydrogenation of Olefins Catalyzed by Flavin Derivatives

黄素衍生物催化烯烃有机催化有氧加氢

• 发表时间: 2006
• 作者: Takahiro;Kitagawa
• 通讯作者: Kitagawa

An electric molecular clip : Redox control for binding ability of cyclic bisflavins

电动分子夹：氧化还原控制环状双黄素的结合能力

• 发表时间: 2007
• 作者: Takashi;Ohno
• 通讯作者: Ohno

Synthesis of macrocyclic polyamines by ring expanding methathesis oligomerization of cyclic nitrones

环状硝酮扩环复分解低聚合成大环多胺

• 发表时间: 2008
• 作者: Chiaki;Okita
• 通讯作者: Okita